ArticleThe Journal of organic chemistry2014
Four-component bicyclization approaches to skeletally diverse pyrazolo[3,4-b]pyridine derivatives.
Article in The Journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 74 citations in OpenAlex.
- Crystal structure of (Acta crystallographica. Section E, Crystallographic communications · 2024Article
- Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles.Topics in current chemistry (Cham) · 2023Review
- A new and straightforward route to synthesize novel pyrazolo[3,4-RSC advances · 2023Article
- An efficient metal-free and catalyst-free C-S/C-O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides.Beilstein journal of organic chemistry · 2023Article
- 5-Amino-pyrazoles: potent reagents in organic and medicinal synthesis.Molecular diversity · 2019Review
- Synthesis of Fluorescent 1,7-Dipyridyl-bis-pyrazolo[3,4-ACS omega · 2019Article
- Grafting of multiwalled carbon nanotubes with pyrazole derivatives: characterization, antimicrobial activity and molecular docking study.International journal of nanomedicine · 2019Article
- Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions.RSC advances · 2018Article
- Cascade bicyclizations of o-alkynyl aldehydes with thiazolium salts: a new access toward poly-functionalized indeno[2,1-b]pyrroles.Chemical communications (Cambridge, England) · 2015Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
A novel four-component bicyclization strategy has been established, allowing a flexible and practical approach to 37 examples of multicyclic pyrazolo[3,4-b]pyridines from low-cost and readily accessible arylglyoxals, pyrazol-5-amines, aromatic amines, 4-hydroxy-6-methyl-2H-pyran-2-one, and cyclohexane-1,3-diones. The polysubstituted cyclopenta[d]pyrazolo[3,4-b]pyridines were stereoselectively synthesized through a microwave-assisted special [3+2+1]/[3+2] bicyclization with good control of the spatial configuration of exocyclic double bonds. The novel [3+2+1]/[2+2+1] bicyclization resulted in 17 examples of unreported pyrazolo[3,4-b]pyrrolo[4,3,2-de]quinolones. Reasonable mechanisms for forming two new types of multicyclic pyrazolo[3,4-b]pyridines are also proposed.
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