ReviewInternational orthopaedics2015
Growth factors in orthopaedic surgery: demineralized bone matrix versus recombinant bone morphogenetic proteins.
Review in International orthopaedics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Revolutionizing Bone Regeneration with Grinder-Based Dentin Biomaterial: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Bone morphogenetic protein use in spine surgery-complications and outcomes: a systematic review.International orthopaedics · 2016Pooled it
- Societe Internationale de Chirurgie Orthopedique et de Traumatologie stardust memories: the past-presidents.International orthopaedics · 2026Article
- Comparative Osteoinductive Potential of BMP-2, Bioactive Glass, and Demineralized Bone Matrix: An In Vitro Alkaline Phosphatase Assay Study.International journal of spine surgery · 2025Article
- Bone fusion materials: past, present, and future.Asian spine journal · 2025Article
- Bone Substitute Options for Spine Fusion in Patients With Spine Trauma-Part I: Fusion Biology, Autografts, Allografts, Demineralized Bone Matrix, and Ceramics.Korean journal of neurotrauma · 2023Review
- Notoginsenoside R1 Promotes Migration, Adhesin, Spreading, and Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stromal Cells.Molecules (Basel, Switzerland) · 2022Article
- Review
- Enhanced osteoinductive capacity and decreased variability by enrichment of demineralized bone matrix with a bone protein extract.Journal of materials science. Materials in medicine · 2018Article
- [Supramalleolar osteotomy in asymmetric ankle osteoarthritis : Short-term clinical and radiographic results].Der Orthopade · 2017Article
- Marshall R. Urist and the discovery of bone morphogenetic proteins.International orthopaedics · 2017Article
- Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration.Frontiers in pharmacology · 2017Article
- Percutaneous injection of bone marrow mesenchymal stem cells for ankle non-unions decreases complications in patients with diabetes.International orthopaedics · 2015Article
- Effect of Qing'e formula on the in vitro differentiation of bone marrow-derived mesenchymal stem cells from proximal femurs of postmenopausal osteoporotic mice.BMC complementary and alternative medicine · 2015Article
- Surgical treatment of aseptic forearm nonunion with plate and opposite bone graft strut. Autograft or allograft?International orthopaedics · 2015Article
- Biological aspects of segmental bone defects management.International orthopaedics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During recent decades the utilisation of growth factors, especially BMPs, has received an increasing interest in orthopaedic surgery. For clinical implantation the two main options are demineralised bone matrix (DBM) and recombinant bone morphogenetic proteins (rhBMP). Many clinical studies agree on an equivalent osteoinductive effect between DBM, BMPs and autologous bone graft; however, the different origins and processing of DBM and rhBMP may introduce some fluctuations. Their respective characteristics are reviewed and possible interactions with their effectiveness are analysed. The main difference concerns the concentration of BMPs, which varies to an order of magnitude of 10(6) between DBM and rhBMPs. This may explain the variability in efficiency of some products and the adverse effects. Currently, considering osteoinductive properties, safety and availability, the DBM seems to offer several advantages. However, if DBM and rhBMPs are useful in some indications, their effectiveness and safety can be improved and more evidence-based studies are needed to better define the indications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.