Evidence map›Paper›PMID 25338077›Full record

ReviewHormones & cancer2015

Genetic predisposition for nonmedullary thyroid cancer.

Rebecca Nagy, Matthew D Ringel

Open access · bronzeAbstract readReview
In one paragraph

Review in Hormones & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Hereditary Renal Cancer Syndromes.Medical sciences (Basel, Switzerland) · 2024
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. The role of SMAD3 in the genetic predisposition to papillary thyroid carcinoma.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Article
  8. Review
  9. The p.G534E variant ofOncotarget · 2017
    Article
  10. Article
  11. Article
  12. HABP2 G534E Mutation in Familial Nonmedullary Thyroid Cancer.Journal of the National Cancer Institute · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rebecca NagyDivison of Human Genetics, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center and Richard G. Solove Research Institute, Columbus, OH, 43210, USA, rebecca.nagy@osumc.edu.
Matthew D Ringel
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Selective Modulation of Thyroidal RadioiodineP01CA124570 · NCI · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2008 to 2017
$23.4M
The Ohio State University and MD Anderson Cancer Center Thyroid Cancer SPOREP50CA168505 · NCI · OHIO STATE UNIVERSITY · PI KIRSCHNER, LAWRENCE S · 2013 to 2017
$10.9M
NCI NIH HHS P01 CA124570NCI NIH HHS P30 CA016058NCI NIH HHS P50 CA168505
6 · The paper itself

Abstract

Nonmedullary thyroid cancer (NMTC) can be sporadic or can occur as a component cancer as part of several well-described hereditary cancer syndromes. NMTC, particularly papillary thyroid cancer, also can occur by itself in families and is often termed familial NMTC or familial papillary thyroid cancer. The occurrence of NMTC in families, along with extensive population-based evidence from patients with sporadic thyroid cancer, together suggest that NMTC has a strong genetic component, only a small proportion of which has been characterized to date. Advances in genetic and genomic technology have rapidly advanced our understanding of the complex nature of NMTC susceptibility, although much remains to be explained. Herein, we describe the current state of knowledge, starting with a brief review of hereditary syndromic causes and moving on to describe recent data using modern genomic approaches to identifying genes involved in the predisposition to NMTC.

Indexed as

Genetic Predisposition to DiseaseCarcinomaCarcinoma, PapillaryGenome-Wide Association StudyHumansNeoplasm GradingNeoplastic Syndromes, HereditaryThyroid Cancer, PapillaryThyroid Neoplasms

Identifiers

PMID25338077
PMCPMC10355960
OpenAlexW1974891591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.