ArticleAnalytical chemistry2014
Achieving reproducible performance of electrochemical, folding aptamer-based sensors on microelectrodes: challenges and prospects.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Label-free paper-based electrochemical aptasensor with tunable selectivity for assessing neurotransmitter imbalance in Alzheimer's disease.Mikrochimica acta · 2026Article
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- Aptamer-Based Scanning Electrochemical Microscopy for Specific and Localized Detection of Analyte Concentration.ACS electrochemistry · 2026Article
- Fundamentals and research progression on electrochemical sensing of colorectal cancer.Mikrochimica acta · 2025Review
- Planar Disk μ-Aptasensors by Monolayer Assembly in a Dissolving Microdroplet.Analytical chemistry · 2024Article
- Microscale, Electrochemical, Aptamer-Based Sensors for Enhanced Small-Molecule Detection at Millisecond Time Scales.ACS sensors · 2023Article
- Perspective-Assessing Electrochemical, Aptamer-Based Sensors for Dynamic Monitoring of Cellular Signaling.ECS sensors plus · 2023Article
- Real-Time Intracellular Analysis of Kanamycin Using Microaptasensors.ACS sensors · 2023Article
- Article
- Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices.Lab on a chip · 2023Review
- Zwitterionic Polymer Coated and Aptamer Functionalized Flexible Micro-Electrode Arrays for In Vivo Cocaine Sensing and Electrophysiology.Micromachines · 2023Article
- Real-Time,ACS sensors · 2022Review
- Accelerated Electron Transfer in Nanostructured Electrodes Improves the Sensitivity of Electrochemical Biosensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Nanoporous Gold for the Miniaturization of In Vivo Electrochemical Aptamer-Based Sensors.ACS sensors · 2021Article
- Realizing new designs of multiplexed electrode chips by 3-D printed masks.RSC advances · 2021Article
- Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring.IEEE journal of solid-state circuits · 2020Article
- A hierarchical 3D camellia-like molybdenum tungsten disulfide architectures for the determination of morphine and tramadol.Mikrochimica acta · 2020Article
- Nonfaradaic Current Suppression in DNA-Based Electrochemical Assays with a Differential Potentiostat.Analytical chemistry · 2019Article
- Bioprospecting solid binding polypeptides for lithium ion battery cathode materials.Biointerphases · 2019Article
- Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in Three-Dimensional Culture Using an Integrated Electrochemical Aptamer-Based Sensor.ACS chemical neuroscience · 2019Article
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5 authors.
Funding
Abstract
Combining specific recognition capabilities with the excellent spatiotemporal resolution of small electrodes represents a promising methodology in bioanalytical and chemical sensing. In this paper, we report the development of reproducible electrochemical, aptamer-based (E-AB) sensors on a gold microelectrode platform. Specifically, we develop microscale sensors (25 μm diameter) for two representative small molecule targets-adenosine triphosphate and tobramycin. Furthermore, we report on the challenges encountered at this size scale including small-magnitude signals and interference from the irreversible reduction of dissolved oxygen and present methods to circumvent these challenges. Through the electrochemical deposition of dendritic gold nanostructures, we demonstrate microscale sensors with improved performance by increasing signal-to-noise and consequently sensitivity. Finally, we report on the use of the nonspecific adsorption of serum proteins as an additional layer of surface passivation for stable sensor performance. The sensor development here represents general guidelines for fabricating electrochemical, folding aptamer-based sensors on small-scale electrodes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.