Evidence map›Paper›PMID 25337710›Full record

ArticlePloS one2014

An emerging mycoplasma associated with trichomoniasis, vaginal infection and disease.

Jennifer M Fettweis, Myrna G Serrano, Bernice Huang, J Paul Brooks, Abigail L Glascock, Nihar U Sheth, Vaginal Microbiome Consortium, Jerome F Strauss, Kimberly K Jefferson, Gregory A Buck

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 71 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Cervicovaginal microbial features predictInfection and immunity · 2025
    Article
  5. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Effect of essential oils fromFrontiers in parasitology · 2025
    Article
  7. Article
  8. Article
  9. Pathogens (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Evolutionary conservation ofFrontiers in microbiology · 2023
    Article
  12. Review
  13. Article
  14. Article
  15. Effect of the Symbiosis withAntibiotics (Basel, Switzerland) · 2022
    Article
  16. Review
  17. High Co-Infection Rate ofHealthcare (Basel, Switzerland) · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jennifer M FettweisDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Myrna G SerranoDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Bernice HuangDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America.
J Paul BrooksDepartment of Statistical Sciences and Operations Research, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Abigail L GlascockDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Nihar U ShethCenter for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Vaginal Microbiome Consortium
Jerome F StraussDepartment of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Kimberly K JeffersonDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Gregory A BuckDepartment of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States of America; Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0M
VCU NIMHD Comprehensive Center of Excellence (Project 1; PI: Strauss)P60MD002256 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI JEFFERSON, KIMBERLY KAY · 2007 to 2016
$13.1M
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54HD080784 · NICHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2014 to 2015
$8.2M
The Vaginal Microbiome: Disease, Genetics and the EnvironmentUH3AI083263 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN · 2010 to 2012
$6.8M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
VCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0M
A Multi-'omic Analysis of the Vaginal Microbiome during PregnancyU54DE023786 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BUCK, GREGORY ALLEN, JEFFERSON, KIMBERLY KAY · 2013 to 2014
$3.0M
NCI NIH HHS 2P30 CA16059NCI NIH HHS P30 CA016059NIAID NIH HHS 4UH3AI083263NIAID NIH HHS UH3 AI083263NICHD NIH HHS 8U54HD080784-02NICHD NIH HHS U54 HD080784NIDCR NIH HHS 1U54DE023786-01NIMHD NIH HHS P60 MD002256NIMHD NIH HHS P60MD002256NIMH NIH HHS T32 MH020030NINDS NIH HHS 5P30NS047463NINDS NIH HHS P30 NS047463
6 · The paper itself

Abstract

Humans are colonized by thousands of bacterial species, but it is difficult to assess the metabolic and pathogenic potential of the majority of these because they have yet to be cultured. Here, we characterize an uncultivated vaginal mycoplasma tightly associated with trichomoniasis that was previously known by its 16S rRNA sequence as "Mnola." In this study, the mycoplasma was found almost exclusively in women infected with the sexually transmitted pathogen Trichomonas vaginalis, but rarely observed in women with no diagnosed disease. The genomes of four strains of this species were reconstructed using metagenome sequencing and assembly of DNA from four discrete mid-vaginal samples, one of which was obtained from a pregnant woman with trichomoniasis who delivered prematurely. These bacteria harbor several putative virulence factors and display unique metabolic strategies. Genes encoding proteins with high similarity to potential virulence factors include two collagenases, a hemolysin, an O-sialoglycoprotein endopeptidase and a feoB-type ferrous iron transport system. We propose the name "Candidatus Mycoplasma girerdii" for this potential new pathogen.

Indexed as

Amino Acid SequenceBacterial ProteinsCoinfectionCommunicable Diseases, EmergingFemaleHumansHydrogen-Ion ConcentrationMembrane ProteinsMolecular Sequence DataMolecular TypingMycoplasmaMycoplasma InfectionsPhylogenyPregnancyPregnancy Complications, InfectiousRNA, BacterialBacterial ProteinsBspA protein, bacteriaMembrane ProteinsRNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID25337710
PMCPMC4206474
OpenAlexW2019298345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.