ArticleJournal of cancer prevention2014
Supplementation of Seaweeds Extracts Suppresses Azoxymethane-induced Aberrant DNA Methylation in Colon and Liver of ICR Mice.
Article in Journal of cancer prevention, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Red Seaweed (Hypnea Bryodies and Melanothamnus Somalensis) Extracts Counteracting Azoxymethane-Induced Hepatotoxicity in RatsAsian Pacific journal of cancer prevention : APJCP · 2016Article
- High-fat diets rich in saturated fat protect against azoxymethane/dextran sulfate sodium-induced colon cancer.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeamustard and seatangle are commonly consumed seaweeds in Korea and rich sources of non-digestible polysaccharides which possess biological activities. However anti-mutagenic and anti-cancer activities of these seaweeds under physiological condition have not been clarified yet. The objective of this study was to investigate the effect of seaweeds consumption on azoxymethane (AOM) -induced DNA methylation at N(7) and O(6) position of guanine base, an indicator of DNA damage related to cancer initiation.
methodsTHIRTY ICR MICE WERE DIVIDED INTO FIVE GROUPS AND FED ONE OF THE FOLLOWING DIETS FOR TWO WEEKS: control diet, diet containing 10% water-soluble or water-insoluble fraction of seamustard or seatangle. After two weeks of experimental diet AOM was injected at 6 hours before sacrifice and N(7)-methylguanine (N(7)-meG) and O(6)-methylguanine (O(6)-meG) from the colon and liver DNA were quantified using a gas chromatography-mass spectroscopy.
resultsWater-soluble fractions of both seamustard and seatangle significantly reduced AOM-induced production of N(7)-meG guanine in colon and liver. Also water-soluble fractions of these seaweeds suppressed the level of methylation at O(6)-guanine of colon and liver directly responsible for tumorigenesis. While water-insoluble fraction of seamustard suppressed the production of N(7)-meG in liver this seaweed fraction decreased O(6)-meG and the ratio of O(6)/N(7)-meG in liver. Water insoluble fraction of seatangle decreased both O(6)- and N(7)-meG in colon and liver. Supplementation of all seaweeds extracts increased fecal weight of animals and the increase of fecal weight by water-insoluble fraction of seaweeds were higher than that by water-soluble fraction.
conclusionSeamustard and seatangle intake may effectively prevent colon and liver carcinogenesis by decreasing DNA damage and the mechanism of inhibiting carcinogenesis by seaweeds in a long term study are warranted.
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