Evidence map›Paper›PMID 25337574›Full record

ArticleJournal of cancer prevention2014

Cellular dynamics after injection of mesoderm-derived human embryonic kidney 293 cells and fibroblasts into developing chick embryos.

Tae Sub Park, Jeong Mook Lim, Ki Hyun Kim, Hee Seung Kim, Yong Sang Song, Jae Yong Han

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer prevention, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tae Sub ParkMajor in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921 ; Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921.
Jeong Mook LimMajor in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921 ; Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921 ; Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.
Ki Hyun KimMajor in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921 ; Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921.
Hee Seung KimDepartment of Obstetrics and Gynecology, College of Medicine, Seoul 110-744 ; Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.
Yong Sang SongMajor in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921 ; Department of Obstetrics and Gynecology, College of Medicine, Seoul 110-744 ; Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.
Jae Yong HanMajor in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921 ; Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-921 ; Interdisciplinary Program in Cancer Biology, Seoul National University College of Medicine, Seoul 110-799, Korea.
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was conducted to compare localization of transformed or differentiated cells after injection into developing chick embryos. Mesoderm-derived chicken embryonic fibroblasts (CEFs), retrieved from normal tissues and artificially transformed human embryonic kidney (HEK) 293 cells, were injected into the dorsal aorta of stage 17 embryos, incubated for 60 h, and post-injection survival and tissue localization after injection were monitored. Overall survival rates were 43% to 57%, and there was no significant difference between the two cell types (P=0.4453). Migration into various tissues was observed after injection of the HEK 293 cells, and this was greatly reduced after CEF transfer (P<0.0127). Tumorigenic activity was detected in the HEK 293 transferred cells and the major organ colonized was the highly vascularized yolk sac. From these results, we suggest that cell transformation alters post-injected migration activity of cells at organogenesis.

Indexed as

Animal cancer modelChicken embryoDifferentiationTumorigenesis

Identifiers

PMID25337574
PMCPMC4189472
OpenAlexW2025246262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.