ArticleBiology of mood & anxiety disorders2014
Insula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression.
Article in Biology of mood & anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurocircuitry and Neuroanatomy in Panic Disorder: A Systematic Review.Alpha psychiatry · 2025Pooled it
- Toward an Embodied Medicine: A Portable Device with Programmable Interoceptive Stimulation for Heart Rate Variability Enhancement.Sensors (Basel, Switzerland) · 2018Trial
- Association between startle reactivity to uncertain threats and structural brain volume.Psychophysiology · 2022Article
- Integrating NIMH's Research Domain Criteria (RDoC) Initiative into Psychiatry Resident Training.Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry · 2022Article
- The neurobiology of misophonia and implications for novel, neuroscience-driven interventions.Frontiers in neuroscience · 2022Review
- Startle during threat longitudinally predicts functional impairment independent of DSM diagnoses.Psychiatry research · 2019Article
- Neural correlates of predictable and unpredictable threat in internalizing psychopathology.Neuroscience letters · 2019Article
- Fear Network Model in Panic Disorder: The Past and the Future.Psychiatry investigation · 2019Article
- Neural hypersensitivity to pleasant touch in women remitted from anorexia nervosa.Translational psychiatry · 2018Article
- Brain abnormalities in cognition, anxiety, and depression regulatory regions in adolescents with single ventricle heart disease.Journal of neuroscience research · 2018Article
- Association between neural reactivity and startle reactivity to uncertain threat in two independent samples.Psychophysiology · 2017Article
- Functional neuroanatomy in panic disorder: Status quo of the research.World journal of psychiatry · 2017Article
- Impact of Panic on Psychophysiological and Neural Reactivity to Unpredictable Threat in Depression and Anxiety.Clinical psychological science : a journal of the Association for Psychological Science · 2017Article
- Startle potentiation to uncertain threat as a psychophysiological indicator of fear-based psychopathology: An examination across multiple internalizing disorders.Journal of abnormal psychology · 2017Article
- Intolerance of uncertainty and insula activation during uncertain reward.Cognitive, affective & behavioral neuroscience · 2016Article
- Functional MRI activation in response to panic-specific, non-panic aversive, and neutral pictures in patients with panic disorder and healthy controls.European archives of psychiatry and clinical neuroscience · 2016Article
- Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation.Neurogastroenterology and motility · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable aversiveness in those with panic disorder (PD) with comorbid major depressive disorder (MDD). The aim of the current study was to examine group differences in neural responses to unpredictable and predictable aversiveness in 41 adults with either 1) current PD with comorbid MDD (PD-MDD), 2) current MDD with no lifetime diagnosis of an anxiety disorder (MDD-only), or 3) no lifetime diagnosis of psychopathology. All participants completed a functional magnetic resonance imaging (fMRI) scan while viewing temporally predictable or unpredictable negative or neutral images.
findingsThe results indicated that individuals with PD-MDD exhibited greater bilateral insula activation to unpredictable aversiveness compared with controls and individuals with MDD-only (who did not differ). There were no group differences in insula activation to predictable aversiveness.
conclusionsThese findings add to a growing literature highlighting the role of the insula in the pathophysiology of anxiety disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.