Evidence map›Paper›PMID 25337302›Full record

ArticleInternational journal of clinical and experimental pathology2014

Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report.

Masatoshi Yamada, Harutaka Katano, Mihoko Yotsumoto, Hirotsugu Hashimoto, Takashi Muramatsu, Mika Shiotsuka, Katsuyuki Fukutake, Masahiko Kuroda

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Masatoshi YamadaDepartment of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
Harutaka KatanoDepartment of Pathology, National Institute of Infectious Disease Tokyo, Japan.
Mihoko YotsumotoDepartment of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
Hirotsugu HashimotoDepartment of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
Takashi MuramatsuDepartment of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
Mika ShiotsukaDepartment of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
Katsuyuki FukutakeDepartment of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
Masahiko KurodaDepartment of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
Tokyo Medical University Hospital · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques. CASE PRESENTATION: Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.

conclusionThese findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.

Indexed as

Antigens, ViralAutopsyBasic-Leucine Zipper Transcription FactorsBiomarkers, TumorCastleman DiseaseCell ProliferationFatal OutcomeHerpesvirus 8, HumanHost-Pathogen InteractionsHumansImmediate-Early ProteinsImmunohistochemistryLymphoma, AIDS-RelatedMaleMiddle AgedNuclear ProteinsAntigens, ViralBasic-Leucine Zipper Transcription FactorsBiomarkers, TumorImmediate-Early ProteinsK8 protein, Human herpesvirus 8latency-associated nuclear antigenNuclear ProteinsRepressor ProteinsRta protein, Human herpesvirus 8Trans-ActivatorsViral ProteinsHHV-8-associated plasmablastic lymphomaHHV-8 latency-associated nuclear antigen 1large B-cell lymphoma arising in HHV8-associated multicentric Castleman’s diseaseopen reading frame 59viral interleukin-6

Identifiers

PMID25337302
PMCPMC4203273
OpenAlexW2210597366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.