ArticleInternational journal of clinical and experimental pathology2014
Malignant perivascular epithelioid cell tumor (PEComa) of cervix with TFE3 gene rearrangement: a case report.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Malignant Perivascular epithelioid cell tumour of the uterus without TFE3 gene rearrangement: a case report.BMC women's health · 2024Article
- Sarcomas With RAD51B Fusions Are Associated With a Heterogeneous Phenotype.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Article
- Cervical PEComa: Challenges in diagnosis and prognosis of a rare neoplasm.Gynecologic oncology reports · 2023Article
- Risk stratification and outcomes in 210 gynecologic perivascular epithelioid cell tumors (PEComas) cases.Archives of gynecology and obstetrics · 2023Review
- Malignant perivascular epithelioid cell tumor (PEComa) of the uterus.BMC women's health · 2022Article
- TFE3-associated perivascular epithelioid cell tumor with complete response to mTOR inhibitor therapy: report of first case and literature review.World journal of surgical oncology · 2022Review
- PEComa of Uterine Cervix.Indian journal of surgical oncology · 2021Article
- Observational
- Perivascular epithelioid cell tumour and mesonephric adenocarcinoma of the uterine cervix: an unknown co-existence.Oxford medical case reports · 2019Article
- Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.The American journal of surgical pathology · 2018Article
- RNA sequencing of Xp11 translocation-associated cancers reveals novel gene fusions and distinctive clinicopathologic correlations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications.The American journal of surgical pathology · 2015Article
- Perivascular epithelioid tumours (PEComas) of the gynaecological tract.Journal of clinical pathology · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we reported the first PEComa arising within the cervix with TFE3 gene rearrangement and aggressive biological behavior. Morphologically, the tumor showed infiltrative growth into the surrounding parenchyma. The majority of tumor cells were arrayed in sheets, alveolar structures, or nests separated by delicate fibrovascular septa. There was marked intratumoral hemorrhage, necrosis, and stromal calcifications. The tumor cells had abundant clear cytoplasm, focally containing finely granular dark brown pigment, morphologically considered to be melanin. Immunohistochemically, the tumor cells demonstrated moderately (2+) or strongly (3+) positive staining for TFE3, HMB45, and Melan A but negative for CKpan, SMA, S100, PAX8, and PAX2. The presence of Ki-67 protein demonstrated a moderate proliferation rate, with a few Ki-67-positive nuclei. Using a recently developed TFE3 split FISH assay, the presence of TFE3 rearrangement was demonstrated. All these clinicopathologic features are suggestive of TFE3-rearranged PEComas of the cervix. Our results both expand the known characteristics of primary cervix PEComas and add to the data regarding TFE3 rearrangement-associated PEComas.
Indexed as
Identifiers
25337301PMC4203272What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.