ReviewInternational journal of clinical and experimental pathology2014
IgG4-related renal disease: clinical and pathological characteristics.
Review in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Complete Treatment Response of Isolated Lacrimal IgG4-Related Disease onMolecular imaging and radionuclide therapy · 2026Article
- Clinical features and outcomes of immunoglobulin G4-related kidney disease and immunoglobulin G4-related retroperitoneal fibrosis in Korea.Kidney research and clinical practice · 2026Article
- IgG4-related kidney disease mimicking renal cell carcinoma: a case report and literature review.Frontiers in medicine · 2026Article
- Coexistence of IgG4-Related Disease and Renal Anastomosing Hemangioma: A Rare Diagnostic Challenge.Internal medicine (Tokyo, Japan) · 2025Article
- Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies.World journal of diabetes · 2024Review
- IgG4-related inflammatory pseudotumor involving the temporal bone disguised as meningioma: a case description and literature analysis.Quantitative imaging in medicine and surgery · 2023Article
- American College of Rheumatology and the European League Against Rheumatism classification criteria for IgG4-related disease: an update for radiologists.Japanese journal of radiology · 2022Review
- The role of imaging in immunoglobulin G4-related disease of the upper urinary tract.Current urology · 2022Article
- A Challenging Diagnosis of IgG4-Related Disease When Understanding Limitations of Laboratory Testing Was Pivotal.Case reports in medicine · 2017Article
- IgG4-Related Kidney Disease in a Patient With History of Breast Cancer: Findings on 18F-FDG PET/CT.Clinical nuclear medicine · 2016Article
- IgG4-related inflammatory pseudotumor of the kidney mimicking renal cell carcinoma: A case report.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgG4-related disease is a recently established systemic condition. Tubulointerstitial nephritis is the most common renal manifestation. Glomerular lesions, particularly membranous glomerulonephritis, can develop simultaneously. Some patients present with serological renal dysfunction associated with elevated IgG or IgE levels and hypocomplementemia, while others are incidentally found to have abnormalities in kidneys on imaging. A majority of patients with IgG4-related kidney disease have similar lesions at other anatomical sites, which help us to suspect this condition. Serum IgG4 elevation (>135 mg/dL) is the most, although not entirely, specific marker for the diagnosis. Imaging findings varies from small nodules to bilateral diffuse abnormalities. In addition to the renal parenchyma, the renal pelvis and perirenal adipose tissue can be affected. Histological features include dense lymphoplasmacytic infiltration, storiform or "bird's eye" fibrosis (highlighted by PAM stain), and IgG4-positive plasma cell infiltration (>10 cells/high-power field and IgG4/IgG-positive cell ratio >40%). Immune complex deposition is detectable in the tubular basement membrane by immunofluorescence and/or electron microscopy. Patients usually respond well to corticosteroids, but highly active diseases may require other immunosuppressive therapies. Further investigations will be required to fully understand pathophysiology underlying this emerging condition.
Indexed as
Identifiers
25337295PMC4203266W1409686286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.