ArticleInternational journal of clinical and experimental pathology2014
A key role of microRNA-29b in suppression of osteosarcoma cell proliferation and migration via modulation of VEGF.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Extracellular vesicle miR-93-5p cargo regulates glomerular endothelial cell damage in Alport syndrome.JCI insight · 2026Article
- The Double Life of microRNAs in Bone Sarcomas: Oncogenic Drivers and Tumor Suppressors.International journal of molecular sciences · 2025Review
- The Role of miR-29s in Human Cancers-An Update.Biomedicines · 2022Review
- The Roles of Noncoding RNAs in the Development of Osteosarcoma Stem Cells and Potential Therapeutic Targets.Frontiers in cell and developmental biology · 2022Review
- Biomarkers mining for spinal cord injury based on integrated multi-transcriptome expression profile data.Journal of orthopaedic surgery and research · 2021Article
- Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b.American journal of cancer research · 2020Article
- miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Serum miR-29b as a novel biomarker for glioblastoma diagnosis and prognosis.International journal of clinical and experimental pathology · 2019Article
- miR-29 Family Inhibits Resistance to Methotrexate and Promotes Cell Apoptosis by Targeting COL3A1 and MCL1 in Osteosarcoma.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells.Archives of toxicology · 2018Article
- Regulatory effects of microRNA‑184 on osteosarcoma via the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2018Article
- miR-141-3p is a key negative regulator of the EGFR pathway in osteosarcoma.OncoTargets and therapy · 2018Article
- miR-493 inhibits proliferation and invasion in pancreatic cancer cells and inversely regulated hERG1 expression.Oncology letters · 2017Article
- [Effect of microRNA-29b on proliferation and migration of breast cancer cells and its molecular mechanism].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Article
- TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals.Oncotarget · 2016Article
- Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma.Journal of experimental & clinical cancer research : CR · 2016Article
- MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6.Protein & cell · 2016Article
- Increased Expression of microRNA-199b-5p Associates with Poor Prognosis Through Promoting Cell Proliferation, Invasion and Migration Abilities of Human Osteosarcoma.Pathology oncology research : POR · 2016Article
- Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA (miRNA) is a small, non-coding RNAs and it could post-transcriptionally related gene expression by negatively regulating the stability or translational efficiency of their target genes. Previous studies have reported the antineoplastic effect of microRNA-29b (miR-29b) in several kinds of cancers. The aim of this study was to investigate the potential role of miR-29b in human osteosarcoma pathogenesis. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to determine the expression level of miR-29b in 20 osteosarcoma specimens and adjacent normal bone tissues. The proliferation, apoptosis, migration and invasion were employed to detect the effect of miR-29b on the osteosarcoma cell line MG63. The results showed that miR-29b expression was relatively decreased in osteosarcoma specimens compared with adjacent normal tissues. Overexpression of miR-29b suppressed MG63 cell proliferation, migration and invasion. Meanwhile miR-29b could induce apoptosis of MG63. Besides, miR-29b directly targets VEGF and over-expression of miR-29b led to down-regulation of VEGF protein level, In conclusions, miR-29b may play an important role in osteosarcoma progression, which might negatively regulate the expression of VEGF and suppresses proliferation and induces apoptosis of MG63 cell line.
Indexed as
Identifiers
25337211PMC4203182W1955464390What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.