ArticleInternational journal of clinical and experimental pathology2014
Triggering the succinate receptor GPR91 enhances pressure overload-induced right ventricular hypertrophy.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Succinate-mediated SUCNR1 activation in tumor-associated macrophages promotes M2 polarization and cetuximab resistance in colorectal cancer: in vitro and in vivo insights.Apoptosis : an international journal on programmed cell death · 2026Article
- Retraction: The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy.PloS one · 2026Article
- Succinate in innate immunity: linking metabolic reprogramming to immune modulation.Frontiers in immunology · 2025Review
- Development and Characterization of Potent Succinate Receptor Fluorescent Tracers.Journal of medicinal chemistry · 2023Article
- Metabolite signaling in the heart.Nature cardiovascular research · 2023Review
- 4'‑O‑methylbavachalcone inhibits succinate induced cardiomyocyte hypertrophy via the NFATc4 pathway.Experimental and therapeutic medicine · 2023Article
- Mitochondrial Damage-associated Molecular Patterns as Potential Biomarkers in DCD Heart Transplantation: Lessons From Myocardial Infarction and Cardiac Arrest.Transplantation direct · 2022Article
- Cardioprotection in right heart failure.British journal of pharmacology · 2020Review
- Article
- A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention.Vessel plus · 2018Article
- Mitochondrial Damage-Associated Molecular Patterns: From Inflammatory Signaling to Human Diseases.Frontiers in immunology · 2018Review
- Metabolism in cardiomyopathy: every substrate matters.Cardiovascular research · 2017Review
- GPR91 deficiency exacerbates allergic contact dermatitis while reducing arthritic disease in mice.Allergy · 2017Article
- Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.Oncotarget · 2017Article
- Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.The journal of trauma and acute care surgery · 2016Article
- The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases.Antioxidants & redox signaling · 2015Article
- Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.Cell communication and signaling : CCS · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary arterial hypertension (PAH) leads to pressure overload in the right ventricle (RV) and induces right ventricular hypertrophy (RVH). GPR91 is an orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate, which increases in RVH; however, its role remains unknown. METHODS AND
resultsWe studied succinate-GPR91 signaling in a pulmonary arterial banding (PAB) model of RVH in the SD rats due to pressure overload. We report that GPR91 was located in cardiomyocytes. We found that the expressions of GPR91 and p-Akt in the RV significantly increased in the PAB model compared with the sham. In the PAB rats, the treatment of succinate further increased the p-Akt levels and aggravated RVH in vivo. In in vitro studies, succinate stimulated the up-regulation of the hypertrophic gene marker anp. All these effects were inhibited by the antagonist of PI3K, wortmannin, both in vivo and in vitro. Finally, we found that the GPR91-PI3K/Akt axis was also up-regulated compared with the sham in human RVH.
conclusionsOur results suggest that succinate-GPR91 is involved in RVH via PI3K/Akt signaling in vivo and in vitro. GPR91 may be a novel therapeutic target for RVH induced by pressure overload.
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Identifiers
25337184PMC4203155W275844747What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.