ReviewInternational journal of chronic obstructive pulmonary disease2014
The causes and consequences of seasonal variation in COPD exacerbations.
Review in International journal of chronic obstructive pulmonary disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05330637 (Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Global Association of Cold Spells and Adverse Health Effects: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2016Pooled it
- Seasonal variations in exacerbations and deaths in patients with COPD during the TIOSPIRInternational journal of chronic obstructive pulmonary disease · 2018Trial
- Erdosteine reduces inflammation and time to first exacerbation postdischarge in hospitalized patients with AECOPD.International journal of chronic obstructive pulmonary disease · 2015Trial
- ACCEPT 3.0: Recalibrating ACute COPD Exacerbation Prediction Tool (ACCEPT) for global use.Diagnostic and prognostic research · 2026Article
- Associations among structural brain alterations, respiratory symptoms and cognitive impairment in patients with chronic obstructive pulmonary disease-related subclinical cognitive vulnerability: a multimodal neuroimaging study.Frontiers in aging neuroscience · 2026Article
- Global trends and future projections of COPD burden under low-temperature risk: a 1990-2041 analysis based on GBD 2021.BMC pulmonary medicine · 2025Article
- Exploring the impact of three meteorological factors and their specific effect sizes on chronic obstructive pulmonary disease admission in Qingyang, China.Scientific reports · 2025Article
- Seasonal and cyclical variations in short-term postoperative outcomes of colorectal cancer: a time series analysis.Scientific reports · 2025Observational
- Comorbidities, Tobacco Exposure, and Geography: Added Risk Factors of Heat and Cold Wave-related Mortality among U.S. Veterans with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2025Article
- Effects of seasonality and treatment on COPD clinical outcomes: IMPACTERJ open research · 2025Article
- New instrument for effective detection of a history of COPD exacerbations, including usually unreported events.Frontiers in medicine · 2025Article
- The role of human rhinovirus in COPD exacerbations in Abu Dhabi: molecular epidemiology and clinical significance.The Libyan journal of medicine · 2024Article
- Google trend analysis of the Indian population reveals a panel of seasonally sensitive comorbid symptoms with implications for monitoring the seasonally sensitive human population.Population health metrics · 2024Article
- Seasonal variations in peptic ulcer disease incidence in Taiwan, a country spanning both tropical and subtropical regions: a real-world database analysis.BMJ open gastroenterology · 2024Article
- Post-pandemic seasonal dynamics of hospitalised COPD exacerbations and aetiologies in the COPD population.ERJ open research · 2024Article
- Racial, biological sex, and geographic disparities of venous thromboembolism in the United States, 2016 to 2019.Journal of vascular surgery. Venous and lymphatic disorders · 2024Article
- Accelerated Lung Function Decline and Mucus-Microbe Evolution in Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2024Observational
- Cold waves and fine particulate matter in high-altitude Chinese cities: assessing their interactive impact on outpatient visits for respiratory disease.BMC public health · 2024Article
- Rate of severe exacerbations, healthcare resource utilisation and clinical outcomes in patients with COPD in low-income and middle-income countries: results from the EXACOS International Study.BMJ open respiratory research · 2024Article
- Heat and Cold Wave-Related Mortality Risk among United States Veterans with Chronic Obstructive Pulmonary Disease: A Case-Crossover Study.Environmental health perspectives · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The time of year when patients experience exacerbations of chronic obstructive pulmonary disease is a much-overlooked feature of the disease. The higher incidence of exacerbations in winter has important consequences for patients in terms of increased morbidity and mortality. The seasonality also imposes a considerable burden on already-overloaded health care services, with both primary care consultations and hospital admissions increasing in number. The seasonality of exacerbations varies with latitude, and is greater in more temperate climates, where there may be less protection from outdoor and indoor cold exposure. The precise causes of the seasonality are unknown, but thought to be partly due to the increased prevalence of respiratory viral infections circulating in cold, damp conditions. Increased susceptibility to viral infection may also be a mechanism mediated through increased airway inflammation or possibly reduced vitamin D levels. The seasonality of exacerbations informs us about the triggers of exacerbations and suggests possible strategies to reduce their number.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.