ArticleDevelopment (Cambridge, England)2014
Spatial gradients of protein-level time delays set the pace of the traveling segmentation clock waves.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif.Development (Cambridge, England) · 2026Article
- DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics.Nature communications · 2025Article
- Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation.Nature communications · 2023Article
- Keeping development on time: Insights into post-transcriptional mechanisms driving oscillatory gene expression during vertebrate segmentation.Wiley interdisciplinary reviews. RNA · 2023Review
- Patterning with clocks and genetic cascades: Segmentation and regionalization of vertebrate versus insect body plans.PLoS genetics · 2021Review
- Time and space in segmentation.Interface focus · 2021Article
- Intrinsic noise, Delta-Notch signalling and delayed reactions promote sustained, coherent, synchronized oscillations in the presomitic mesoderm.Journal of the Royal Society, Interface · 2019Article
- Regulatory Network of the Scoliosis-Associated Genes Establishes Rostrocaudal Patterning of Somites in Zebrafish.iScience · 2019Article
- Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation.Development (Cambridge, England) · 2018Article
- Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling.Cell reports · 2018Article
- ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock.Development (Cambridge, England) · 2018Article
- A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila.PLoS biology · 2018Article
- Modeling the Notch Response.Advances in experimental medicine and biology · 2018Review
- The kinetics in mathematical models on segmentation clock genes in zebrafish.Journal of mathematical biology · 2018Article
- Recent advances in understanding vertebrate segmentation.F1000Research · 2018Review
- Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation.Development (Cambridge, England) · 2017Article
- Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation.Developmental biology · 2017Article
- Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock.eLife · 2016Article
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8 authors.
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Abstract
The vertebrate segmentation clock is a gene expression oscillator controlling rhythmic segmentation of the vertebral column during embryonic development. The period of oscillations becomes longer as cells are displaced along the posterior to anterior axis, which results in traveling waves of clock gene expression sweeping in the unsegmented tissue. Although various hypotheses necessitating the inclusion of additional regulatory genes into the core clock network at different spatial locations have been proposed, the mechanism underlying traveling waves has remained elusive. Here, we combined molecular-level computational modeling and quantitative experimentation to solve this puzzle. Our model predicts the existence of an increasing gradient of gene expression time delays along the posterior to anterior direction to recapitulate spatiotemporal profiles of the traveling segmentation clock waves in different genetic backgrounds in zebrafish. We validated this prediction by measuring an increased time delay of oscillatory Her1 protein production along the unsegmented tissue. Our results refuted the need for spatial expansion of the core feedback loop to explain the occurrence of traveling waves. Spatial regulation of gene expression time delays is a novel way of creating dynamic patterns; this is the first report demonstrating such a control mechanism in any tissue and future investigations will explore the presence of analogous examples in other biological systems.
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