Evidence map›Paper›PMID 25336577›Full record

ArticleThe British journal of ophthalmology2015

Outcomes of ab interno trabeculectomy with the trabectome by degree of angle opening.

I I Bussel, K Kaplowitz, J S Schuman, N A Loewen, Trabectome Study Group

2 registry-linked trialsAbstract read
In one paragraph

Article in The British journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02964676 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Clinical Efficacy and Safety of Minimally Invasive Glaucoma Surgery on Chinese Primary Angle Closure Glaucoma

TypeinterventionalSponsorShanghai Eye Disease Prevention and Treatment CenterRan2017 to 2019Enrolled246ConditionsGlaucoma, Angle-ClosureArmsab interno trabeculectomy with Trabectome, trabeculectomy
NCT03138928 completednot on this map

XEN45 Gel Stent Implantation in Glaucoma Surgery

TypeobservationalSponsorTrakya UniversityRan2015 to 2017Enrolled15ConditionsGlaucoma EyeArmsXEN45 gel stent implantation in glaucoma surgery
3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Visual Function After Schlemm's Canal-Based MIGS.Journal of clinical medicine · 2025
    Review
  2. Article
  3. VEGF-A-induced changes in distal outflow tract structure and function.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  4. Article
  5. Review
  6. Gonioscopy-assisted transluminal trabeculotomy in primary angle-closure glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  7. Article
  8. Article
  9. Exact matching of trabectome-mediated ab interno trabeculectomy to conventional trabeculectomy with mitomycin C followed for 2 years.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  10. Review
  11. Dose-dependent effects of netarsudil, a Rho-kinase inhibitor, on the distal outflow tract.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  12. Can a contact lens sensor predict the success of trabectome surgery?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  13. Article
  14. Article
  15. Review
  16. XEN implant device versus trabeculectomy, either alone or in combination with phacoemulsification, in open-angle glaucoma patients.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  17. Five-year clinical outcomes of combined phacoemulsification and trabectome surgery at a single glaucoma center.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

I I BusselDepartment of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
K KaplowitzDepartment of Ophthalmology, Stony Brook University School of Medicine, Stony Brook, New York, USA.
J S SchumanDepartment of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
N A LoewenDepartment of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Trabectome Study Group

Funding

Reverse Engineering of Trabecular MeshworkK08EY022737 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOEWEN, NILS A · 2012 to 2016
$993k
NEI NIH HHS K08 EY022737
6 · The paper itself

Abstract

aimTo analyse ab interno trabeculectomy (AIT) with the trabectome and combined phacoemulsification with AIT (phaco-AIT) by Shaffer angle grade (SG).

methodsProspective study of AIT and phaco-AIT with narrow angles of SG≤2 versus open angles ≥3. Outcomes included intraocular pressure (IOP), medications, complications, secondary surgery and success (IOP <21 mm Hg and >20% reduction without further surgery). Exclusion criteria were missing preoperative data and <1 year follow-up.

resultsOf 671 included cases, at 1 year AIT SG≤2 (n=43) had an IOP reduction of 42% from 27.3±7.4 to 15.7±3.0 mm Hg (p<0.01) versus AIT SG≥3 (n=271) with an IOP reduction of 37% from 26.1±7.8 to 16.4±3.9 mm Hg (p<0.01). In phaco-AIT with SG≤2 (n=48), IOP was reduced 24% from 20.7±7.0 to 15.7±3.6 mm Hg (p<0.01) versus phaco-AIT with SG≥3 (n=309) with an IOP reduction of 25% from 22.6±6.4 to 17.0±3.4 mm Hg (p<0.01). There was no difference between SG≤2 and SG≥3 in reduction of IOP or medications, complications, secondary surgery and success rates (p>0.05).

conclusionsSG≤2 is not associated with worse outcomes in AIT or phaco-AIT.

Indexed as

PhacoemulsificationAdolescentAdultAgedAged, 80 and overAnterior ChamberAntihypertensive AgentsAqueous HumorFemaleFollow-Up StudiesGlaucomaHumansIntraocular PressureMaleMiddle AgedMinimally Invasive Surgical ProceduresAntihypertensive AgentsAngleAnterior chamberGlaucomaTreatment Surgery

Identifiers

PMID25336577
PMCPMC4501175

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.