Evidence map›Paper›PMID 25336410›Full record

ArticleAlcoholism, clinical and experimental research2014

Effects of cigarette smoking history on neurocognitive recovery over 8 months of abstinence in alcohol-dependent individuals.

Timothy C Durazzo, David L Pennington, Thomas P Schmidt, Dieter J Meyerhoff

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Article
  7. Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Brain Structure and Function in Recovery.Alcohol research : current reviews · 2020
    Review
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy C DurazzoCenter for Imaging of Neurodegenerative Diseases (CIND) , San Francisco VA Medical Center, San Francisco, California; Department of Radiology and Biomedical Imaging , University of California, San Francisco, California.
David L Pennington
Thomas P Schmidt
Dieter J Meyerhoff

Funding

The Biological Basis of Alcohol Induced Brain DamageR01AA010788 · NIAAA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MEYERHOFF, DIETER J · 1996 to 2016
$8.9M
The Neurobiological and Neurocognitive Consequences of Chronic Cigarette SmokingK01DA024136 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DURAZZO, TIMOTHY CRAIG · 2008 to 2012
$785k
NIAAA NIH HHS AA10788NIAAA NIH HHS R01 AA010788NIDA NIH HHS DA24136NIDA NIH HHS K01 DA024136
6 · The paper itself

Abstract

backgroundThis study compared the rate and extent of recovery on measures of learning and memory, processing speed, and working memory in treatment-seeking alcohol-dependent individuals (ALC) who were never smokers (nvsALC), former smokers (fsALC), and active smokers (asALC) over the first 8 months of sustained abstinence from alcohol. Assessments after 1 week, 1 month, and 8 months of abstinence in ALC enabled a comparison of the rates of neurocognitive changes from 1 week to 1 month versus 1 to 8 months of abstinence.

methodsALC and never-smoking controls were administered standardized measures of auditory-verbal and visuospatial learning and memory, processing speed, and working memory. Controls completed a baseline assessment and a follow-up approximately 9 months later.

resultsOver 8 months of abstinence, asALC showed poorer recovery than nvsALC on visuospatial learning, and both fsALC and asALC recovered less than nvsALC on processing speed measures. The corresponding recovery rates for the ALC group, as a whole, were greater from 1 week to 1 month than from 1 to 8 months of abstinence; these findings were largely driven by improvements in nvsALC. The recovery levels for fsALC on most measures were similar to those in asALC. Additionally, over 8 months, asALC showed significantly less improvement with increasing age than nvsALC on measures of processing speed and learning and memory. At 8 months of abstinence, asALC were inferior to controls and nvsALC on multiple measures, fsALC performed worse than nvsALC on several tests, but nvsALC were not different from controls on any measure.

conclusionsOverall, ALC showed rapid improvement on measures of visuospatial learning and processing speed during the first month of abstinence from alcohol. Results also provide robust evidence that smoking status influenced the rate and level of neurocognitive recovery over 8 months of abstinence in this ALC cohort.

Indexed as

CognitionNeuropsychological TestsRecovery of FunctionAdultAgedAlcoholismCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMemory, Short-TermMiddle AgedSmokingTemperanceAlcohol DependenceCigarette SmokingCognitionLongitudinalRecovery

Identifiers

PMID25336410
PMCPMC4245379

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.