Evidence map›Paper›PMID 25335960›Full record

ArticleBMJ open2014

Gene-environment interaction involved in cholangiocarcinoma in the Thai population: polymorphisms of DNA repair genes, smoking and use of alcohol.

Nopparat Songserm, Supannee Promthet, Chamsai Pientong, Tipaya Ekalaksananan, Peechanika Chopjitt, Surapon Wiangnon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Risk Factors for Cholangiocarcinoma in Thailand: A Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nopparat SongsermDepartment of Community Health, Faculty of Public Health, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, Thailand.
Supannee PromthetDepartment of Epidemiology, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
Chamsai PientongDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Tipaya EkalaksanananDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Peechanika ChopjittDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Surapon WiangnonDepartment of Paediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Khon Kaen University · THUbon Ratchathani Rajabhat University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCholangiocarcinoma (CCA) is the most common malignancy in a Northeast Thai population. Smoking and alcohol drinking are associated with the production of free radical intermediates, which can cause several types of DNA lesions. Reduced repair of these DNA lesions would constitute an important risk factor for cancer development. We therefore examined whether polymorphisms in DNA base-excision repair (BER) genes, XRCC1 G399A and OGG1 C326G, were associated with CCA risk and whether they modified the effect of smoking and alcohol drinking in the Thai population.

designA nested case-control study within the cohort study was conducted: 219 participants with primary CCA were each matched with two non-cancer controls from the same cohort on sex, age at recruitment and the presence/absence of Opisthorchis viverrini eggs in stools. Smoking and alcohol consumption were assessed on recruitment. Polymorphisms in BER genes were analysed using a PCR with high-resolution melting analysis. The associations were assessed using conditional logistic regression.

resultsOur results suggest that, in the Thai population, polymorphisms in XRCC1 and OGG1 genes, particularly in combination, are associated with increased susceptibility to CCA, and that their role as modifiers of the effect of smoking and alcohol consumption influences the risk of CCA.

conclusionsBetter ways of reducing habitual smoking and alcohol consumption, targeted towards subgroups which are genetically susceptible, are recommended. CCA is a multifactorial disease, and a comprehensive approach is needed for its effective prevention. This approach would also have the additional advantage of reducing the onset of other cancers.

Indexed as

Bile Ducts, IntrahepaticGene-Environment InteractionAdultAgedAlcohol DrinkingAsian PeopleBile Duct NeoplasmsCase-Control StudiesCholangiocarcinomaDNA-Binding ProteinsDNA GlycosylasesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedDNA-Binding ProteinsDNA Glycosylasesoxoguanine glycosylase 1, humanX-ray Repair Cross Complementing Protein 1XRCC1 protein, humanEPIDEMIOLOGYPUBLIC HEALTH

Identifiers

PMID25335960
PMCPMC4208049
OpenAlexW2137018550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.