ArticleImmunogenetics2015
Composition and variation analysis of TCR β-chain CDR3 repertoire in the thymus and spleen of MRL/lpr mouse at different ages.
Article in Immunogenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE.Lupus science & medicine · 2025Article
- Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice.Immunity & ageing : I & A · 2021Article
- The T Cell Receptor Repertoire in Neuropsychiatric Systemic Lupus Erythematosus.Frontiers in immunology · 2020Article
- Preliminary analysis of spatial-temporal homogeneity and heterogeneity of TCR β chain CDR3 repertoires in BALB/c mice.International journal of molecular epidemiology and genetics · 2019Article
- Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells play an important role in the onset and progression of systemic lupus erythematosus (SLE), and the biases in T cell receptor beta variable (TRBV) region families and complementarity determining region three (CDR3) composition in SLE patients and mouse models have been widely reported. However, the relationship between the composition and variation in the TCR β-chain CDR3 repertoire and SLE has not been established. Here, we compared and analyzed the thymic and splenic TCR β-chain CDR3 mRNA sequences by Roche 454 high-throughput sequencing from MRL/lpr mice at different ages. Our results indicate that diversity in the TCR CDR3 repertoire from the thymus and spleen from MRL/lpr mouse was significantly decreased with increased age (disease progression) and showed a bias in usage of common TRBV and TRBJ families. The N1 region insertions in the highly expressed CDR3s significantly increased with disease progression. This study provides a new perspective for studying SLE with progression of disease in clonal level of TCR, which may provide a basis for studying the mechanism of the MRL/lpr autoreactive T cells response and tailor an individualized treatment targeting these T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.