ArticleThe Journal of antibiotics2015
Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones.
Article in The Journal of antibiotics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Probiogenomic analysis of functional potential and safety ofMicrobiology spectrum · 2026Article
- Efficacy of furanone in reducing the bacterial contamination and marginal bone loss of dental implants.Scientific reports · 2025Article
- New BacteriophageViruses · 2025Article
- Dishwashing liquids with nuclease and protease: An improved biocompatible solution for the removal of adherent bacteria from fruits and vegetables.AIMS microbiology · 2025Article
- 3,4-Dihalo-5-hydroxy-2(5Molecules (Basel, Switzerland) · 2024Review
- The Antimicrobial Potential of the Hop (Pharmaceuticals (Basel, Switzerland) · 2024Article
- The Effect of Ficin Immobilized on Carboxymethyl Chitosan on Biofilms of Oral Pathogens.International journal of molecular sciences · 2023Article
- Titanium complexes affectRSC medicinal chemistry · 2023Article
- Alterations in Antibiotic Susceptibility ofInternational journal of molecular sciences · 2023Article
- The Novel Chiral 2(5Molecules (Basel, Switzerland) · 2023Article
- Efficient Inhibition of Bacterial Biofilm Through Interference of Protein-Protein Interaction of Master Regulator Proteins: a Proof of Concept Study with SinR- SinI Complex of Bacillus subtilis.Applied biochemistry and biotechnology · 2023Article
- Antimicrobial and Biofilm-Preventing Activity of l-Borneol Possessing 2(5H)-Furanone Derivative F131 against S. aureus—C. albicans Mixed CulturesPathogens (Basel, Switzerland) · 2022Article
- Increasing the Efficacy of Treatment ofAntibiotics (Basel, Switzerland) · 2022Article
- Novel Biocatalysts Based on Bromelain Immobilized on Functionalized Chitosans and Research on Their Structural Features.Polymers · 2022Article
- The Bovhyaluronidase Azoximer (LongidazaMedicina (Kaunas, Lithuania) · 2022Article
- Hazelnut Shells as Source of Active Ingredients: Extracts Preparation and Characterization.Molecules (Basel, Switzerland) · 2021Article
- Improving the Efficacy of Antimicrobials against Biofilm-Embedded Bacteria Using Bovine Hyaluronidase Azoximer (LongidazaPharmaceutics · 2021Article
- In Vivo Biological Evaluation of Biodegradable Nanofibrous Membranes Incorporated with Antibiofilm Compounds.Polymers · 2021Article
- Article
- Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone)-F8 and F12-were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones. Therefore, our data confirm that furanones affect significantly the regulatory pathway(s) leading to biofilm formation. We propose that the global regulator, Spo0A, is one of the potential putative cellular targets for these compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.