Evidence map›Paper›PMID 25335641›Full record

ArticleRadiation and environmental biophysics2015

Metabolic oxygen consumption measurement with a single-cell biosensor after particle microbeam irradiation.

Yanping Xu, Bo Zhang, Mark Messerli, Gerhard Randers-Pehrson, Tom K Hei, David J Brenner

Abstract read
In one paragraph

Article in Radiation and environmental biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Real-time local oxygen measurements for high resolution cellular imaging.Journal of molecular and cellular cardiology · 2019
    Article
  2. A Horizontal Multi-Purpose Microbeam System.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanping XuRadiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, 136 S. Broadway, Irvington, NY, 10533, USA. yx2132@columbia.edu.
Bo ZhangCenter for Radiological Research, Columbia University, New York, NY, 10032, USA.
Mark MesserliBiocurrents Research Center, Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Gerhard Randers-PehrsonRadiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, 136 S. Broadway, Irvington, NY, 10533, USA.
Tom K HeiCenter for Radiological Research, Columbia University, New York, NY, 10032, USA.
David J BrennerRadiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, 136 S. Broadway, Irvington, NY, 10533, USA.

Funding

THE FUNCTIONAL GENOMICS OF BYSTANDER RESPONSESP01CA049062 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HEI, TOM K. · 1990 to 2014
$21.9M
TR&D 3P41EB002033 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRENNER, DAVID JONATHAN · 2003 to 2018
$17.0M
NCI NIH HHS P01 CA049062NCI NIH HHS P01-CA49062-22NIBIB NIH HHS P41 EB002033NIBIB NIH HHS P41EB002033
6 · The paper itself

Abstract

A noninvasive, self-referencing biosensor/probe system has been integrated into the Columbia University Radiological Research Accelerator Facility Microbeam II end station. A single-cell oxygen consumption measurement has been conducted with this type of oxygen probe in 37° C Krebs-Ringer Bicarbonate buffer immediately before and after a single-cell microbeam irradiation. It is the first such measurement made for a microbeam irradiation, and a six fold increment of oxygen flux induced during a 15-s period of time has been observed following radiation exposure. The experimental procedure and the results are discussed.

Indexed as

Biosensing TechniquesOxygen ConsumptionParticle AcceleratorsCell LineElectrodesHumansRadiobiology

Identifiers

PMID25335641
PMCPMC4437628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.