ArticleScientific reports2014
Lab-on-a-brain: implantable micro-optical fluidic devices for neural cell analysis in vivo.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Microfluidic technologies for wearable and implantable biomedical devices.Lab on a chip · 2025Review
- Article
- Shallow-angle intracranial cannula for repeated infusion andNeurophotonics · 2025Article
- Toolkit for integrating millimeter-sized microfluidic biomedical devices with multiple membranes and electrodes.Microsystems & nanoengineering · 2025Article
- Shallow-angle intracranial cannula for repeated infusion and in vivo imaging with multiphoton microscopy.bioRxiv : the preprint server for biology · 2025Article
- Addressable microfluidics technology for non-sacrificial analysis of biomaterial implantsBiomicrofluidics · 2023Article
- Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation.RSC advances · 2022Review
- A Hybrid Titanium-Softmaterial, High-Strength, Transparent Cranial Window for Transcranial Injection and Neuroimaging.Biosensors · 2022Article
- The Shape of μ-How Morphological Analyses Shape the Study of Microglia.Frontiers in cellular neuroscience · 2022Review
- Multiphoton intravital microscopy of rodents.Nature reviews. Methods primers · 2022Article
- Through the looking glass: A review of cranial window technology for optical access to the brain.Journal of neuroscience methods · 2021Review
- Self-Reset Image Sensor With a Signal-to-Noise Ratio Over 70 dB and Its Application to Brain Surface Imaging.Frontiers in neuroscience · 2021Article
- Biomedical and Tissue Engineering Strategies to Control Foreign Body Reaction to Invasive Neural Electrodes.Frontiers in bioengineering and biotechnology · 2021Review
- Impacts of the murine skull on high-frequency transcranial photoacoustic brain imaging.Journal of biophotonics · 2019Article
- Skull optical clearing window forLight, science & applications · 2018Article
- Invasive Intraneural Interfaces: Foreign Body Reaction Issues.Frontiers in neuroscience · 2017Review
- A soft, transparent, freely accessible cranial window for chronic imaging and electrophysiology.Scientific reports · 2016Article
- Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo.Scientific reports · 2016Article
- Intravital fluorescence imaging of mouse brain using implantable semiconductor devices and epi-illumination of biological tissue.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high-resolution imaging of neural cells in vivo has brought about great progress in neuroscience research. Here, we report a novel experimental platform, where the intact brain of a living mouse can be studied with the aid of a surgically implanted micro-optical fluidic device; acting as an interface between neurons and the outer world. The newly developed device provides the functions required for the long-term and high-resolution observation of the fine structures of neurons by two-photon laser scanning microscopy and the microfluidic delivery of chemicals or drugs directly into the brain. A proof-of-concept experiment of single-synapse stimulation by two-photon uncaging of caged glutamate and observation of dendritic spine shrinkage over subsequent days demonstrated a promising use for the present technology.
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