SynthesisEuropean journal of clinical nutrition2015
The relationship between zinc intake and growth in children aged 1-8 years: a systematic review and meta-analysis.
Synthesis in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Enteral zinc supplementation for prevention of morbidity and mortality in preterm neonates.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- The Impact of Nutritional Interventions beyond the First 2 Years of Life on Linear Growth: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2017Pooled it
- The effect of zinc supplementation on body composition and hormone levels related to adiposity among children: a systematic review.Public health nutrition · 2016Pooled it
- Choline in Adolescent Pregnancy: The Impact on Fetal Brain Development and Long-Term Cognitive Outcomes of Offspring.Medicina (Kaunas, Lithuania) · 2025Review
- Are boys more vulnerable to stunting? Examining risk factors, differential sensitivity, and measurement issues in Zambian infants and young children.BMC public health · 2024Article
- Nutritional Strategies for the Prevention and Management of Cow's Milk Allergy in the Pediatric Age.Nutrients · 2023Review
- Biofortification of common bean (Food and energy security · 2023Review
- Micronutrients and Nutrition Status of School-Aged Children in Indonesia.Journal of nutrition and metabolism · 2023Article
- Development of Food Multi-Mix Using a Linear Programming Approach to Fill the Nutrient Gap of Amino Acids and Micronutrients for Stunted Non-Wasted Children.Foods (Basel, Switzerland) · 2022Article
- Immune System and Psychological State of Pregnant Women during COVID-19 Pandemic: Are Micronutrients Able to Support Pregnancy?Nutrients · 2022Review
- Zinc Intakes and Health Outcomes: An Umbrella Review.Frontiers in nutrition · 2022Review
- Individual, household and national factors associated with iron, vitamin A and zinc deficiencies among children aged 6-59 months in Nepal.Maternal & child nutrition · 2022Article
- Animal source foods, rich in essential amino acids, are important for linear growth and development of young children in low- and middle-income countries.Maternal & child nutrition · 2022Review
- Minerals in Pregnancy and Their Impact on Child Growth and Development.Molecules (Basel, Switzerland) · 2020Review
- Environmental exposure to metal mixtures and linear growth in healthy Ugandan children.PloS one · 2020Article
- Measuring energy, macro and micronutrient intake in UK children and adolescents: a comparison of validated dietary assessment tools.BMC nutrition · 2019Article
- Zinc and Skin Disorders.Nutrients · 2018Review
- Assessing dietary intakes from household budget surveys: A national analysis in Bangladesh.PloS one · 2018Article
- Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.Advances in nutrition (Bethesda, Md.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesIt is estimated that zinc deficiency affects 17% of the world's population, and because of periods of rapid growth children are at an increased risk of deficiency, which may lead to stunting. This paper presents a systematic review and meta-analysis of the randomised controlled trials (RCTs) that assess zinc intake and growth in children aged 1-8 years. This review is part of a larger systematic review by the European Micronutrient Recommendations Aligned Network of Excellence that aims to harmonise the approach to setting micronutrient requirements for optimal health in European populations (www.eurreca.org). SUBJECT/
methodsSearches were performed of literature published up to and including December 2013 using MEDLINE, Embase and the Cochrane Library databases. Included studies were RCTs in apparently healthy child populations aged from 1 to 8 years that supplied zinc supplements either as capsules or as part of a fortified meal. Pooled meta-analyses were performed when appropriate.
resultsNine studies met the inclusion criteria. We found no significant effect of zinc supplementation of between 2 weeks and 12 months duration on weight gain, height for age, weight for age, length for age, weight for height (WHZ) or WHZ scores in children aged 1-8 years.
conclusionsMany of the children in the included studies were already stunted and may have been suffering from multiple micronutrient deficiencies, and therefore zinc supplementation alone may have only a limited effect on growth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.