ArticleTranslational psychiatry2014
High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04159207 (A Longitudinal Study of Inflammatory Pathways in Depression), which is not on this map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Longitudinal Study of Inflammatory Pathways in Depression
Who cites it
47 citing papers in PubMed, 85 citations in OpenAlex.
- Suicide mortality in metabolic dysfunction-associated liver diseases: a nationwide cohort study.Annals of medicine · 2026Article
- Low 5HTJournal of neurochemistry · 2026Review
- Joint effects of sleep duration and sleep difficulty on suicidal ideation: evidence from NHANES 2005-2018.BMC psychiatry · 2026Article
- Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis.Annals of general psychiatry · 2025Article
- Epigenetics and immunology: Under-recognized aspects of suicidality.World journal of psychiatry · 2025Review
- Alterations of pro- and anti-inflammatory cytokines balance and superoxide dismutase in the dorsolateral prefrontal cortex of suicide decedents.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- The role of cytokines in predicting the therapeutic effect of non-suicidal self-injury in adolescents: a longitudinal study.BMC psychiatry · 2025Article
- Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Association between cytokines and suicidality in patients with psychosis: A multicentre longitudinal analysis.Brain, behavior, & immunity - health · 2024Article
- Associations between antipsychotics-induced weight gain and brain networks of impulsivity.Translational psychiatry · 2024Article
- Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates.Frontiers in immunology · 2024Review
- Associations of pro-inflammatory factors and IL-10 levels with degree of suicide risk in adolescents with depression.Frontiers in psychiatry · 2024Article
- Article
- Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients.Neuropsychiatric disease and treatment · 2023Article
- Suicide and Inflammation.Advances in experimental medicine and biology · 2023Article
- C-Reactive Protein as a Potential Peripheral Biomarker for High-Lethality Suicide Attempts.Life (Basel, Switzerland) · 2022Article
- Altered Levels of Plasma Inflammatory Cytokines and White Matter Integrity in Bipolar Disorder Patients With Suicide Attempts.Frontiers in psychiatry · 2022Article
- Interleukin-8 and tumor necrosis factor-alpha in youth with mood disorders-A longitudinal study.Frontiers in psychiatry · 2022Article
- New frontiers in suicide vulnerability: immune system and sex hormones.Brain, behavior, & immunity - health · 2021Article
- Psychoneuroimmunology: The new frontier in suicide research.Brain, behavior, & immunity - health · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dysregulation of inflammation has been associated with depression and, more recently, with suicidal behaviors. The reports regarding the relationship between interleukin-6 (IL-6) and suicide attempts are inconsistent. Personality traits such as impulsivity and aggression are considered endophenotypes and important factors that underlie suicidal behaviors. The aim of the current study was to assess whether plasma and cerebrospinal fluid (CSF) levels of IL-6 are associated with personality traits among suicide attempters. We assessed the relationships among personality traits, IL-6 and violent suicide attempts. The plasma and CSF levels of IL-6 were measured in suicide attempters (plasma=58, CSF=39) using antibody-based immunoassay systems. Personality domains were assessed using the Karolinska Scale of Personality (KSP). IL-6 levels in plasma and CSF were used to predict personality domains via regression models. Plasma IL-6 was significantly and positively correlated with extraversion as well as the KSP subscales impulsivity and monotony avoidance. CSF IL-6 was positively correlated with monotony avoidance. Violent suicide attempts tended to be associated with high plasma IL-6 levels. Plasma and CSF levels of IL-6 were not significantly associated with each other. These results indicate that impulsivity and the choice of a violent suicide attempt method might be related to higher levels of IL-6 in individuals who attempt suicide. The neuroinflammation hypothesis of suicidal behavior on the basis of elevated IL-6 levels might be partly explained by the positive association between IL-6 and impulsivity, which is a key element of the suicidal phenotype.
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Registered trials
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