Evidence map›Paper›PMID 25334030›Full record

ArticleNature communications2014

Genome flux and stasis in a five millennium transect of European prehistory.

Cristina Gamba, Eppie R Jones, Matthew D Teasdale, Russell L McLaughlin, Gloria Gonzalez-Fortes, Valeria Mattiangeli, László Domboróczki, Ivett Kővári, Ildikó Pap, Alexandra Anders and 7 more

Abstract readHistorical Article
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 313 papers.

0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

313 citing papers in PubMed.

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  13. On the Edge of Empire: Paleogenomic Insights into Roman Dacia.bioRxiv : the preprint server for biology · 2026
    Article
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  15. Review
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253 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cristina Gamba1] School of Archaeology, University College Dublin, Belfield, Dublin 4, Ireland [2] Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland [3] Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Eppie R JonesSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Matthew D TeasdaleSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Russell L McLaughlinSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Gloria Gonzalez-FortesInstitute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476 Potsdam, Germany.
Valeria MattiangeliSmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
László DomboróczkiDobó István Castle Museum, Vár utca 1, H-3300 Eger, Hungary.
Ivett KőváriJPAC-Central Identification Laboratory, 310 Worchester Avenue, Building. 45 Joint Base Pearl Harbor-Hickam, Honalulu, Hawaii 96853-5530, USA.
Ildikó PapDepartment of Anthropology, Hungarian Natural History Museum, Ludovika tér 2-6, 1083 Budapest, Hungary.
Alexandra AndersEötvös Loránd University, Faculty of Humanities, Institute of Archaeological Sciences, Múzeum körút 4/b, H-1o88 Budapest, Hungary.
Alasdair WhittleDepartment of Archaeology and Conservation, Cardiff University, Cardiff CF10 3EU, UK.
János DaniDéri Museum, Déri tér 1, H-4026 Debrecen, Hungary.
Pál RaczkyEötvös Loránd University, Faculty of Humanities, Institute of Archaeological Sciences, Múzeum körút 4/b, H-1o88 Budapest, Hungary.
Thomas F G HighamOxford Radiocarbon Accelerator Unit, Research Laboratory for Archaeology and the History of Art, University of Oxford, Dyson Perrins Building, South Parks Road, OX1 3QY Oxford, UK.
Michael HofreiterInstitute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Straße 24-25, 14476 Potsdam, Germany.
Daniel G BradleySmurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
Ron Pinhasi1] School of Archaeology, University College Dublin, Belfield, Dublin 4, Ireland [2] Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland [3] Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland [4] Earth Institute, University College Dublin, Belfield, Dublin 4, Ireland.

Funding

European Research Council 263441
6 · The paper itself

Abstract

The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (~22 × ) and seven to ~1 × coverage, to investigate the impact of these on Europe's genetic landscape. These data suggest genomic shifts with the advent of the Neolithic, Bronze and Iron Ages, with interleaved periods of genome stability. The earliest Neolithic context genome shows a European hunter-gatherer genetic signature and a restricted ancestral population size, suggesting direct contact between cultures after the arrival of the first farmers into Europe. The latest, Iron Age, sample reveals an eastern genomic influence concordant with introduced Steppe burial rites. We observe transition towards lighter pigmentation and surprisingly, no Neolithic presence of lactase persistence.

Indexed as

Genetics, PopulationGenome, HumanEthnicityEuropeGenomic InstabilityGenomicsGenotypeHistory, AncientHomozygoteHumansPhenotypePopulation DensityPrincipal Component AnalysisSequence Analysis, DNASkin PigmentationTime Factors

Identifiers

PMID25334030
PMCPMC4218962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.