ArticlePloS one2014
The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
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- Historical comparative genomics to track the evolution of fungal pathogens: a proof of concept.BMC genomics · 2026Article
- Comparative transcriptomics reveal contrasting strategies between a fungal plant pathogen and an endophyte during initial host colonization.Microbiology spectrum · 2025Article
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- A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis.PLoS pathogens · 2025Article
- Mycological and Genomic Characterization of Fusarium vorosii, a Potentially Pathogenic Fungus, Isolated from Field Crops and Weeds in Korea.The plant pathology journal · 2024Article
- Identification and Confirmation of Virulence Factor Production fromJournal of fungi (Basel, Switzerland) · 2024Article
- Six type-I PKS classes and highly conserved melanin and elsinochrome gene clusters found in diverse Elsinoë species.BMC genomics · 2024Article
- Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium.Microbial cell factories · 2024Review
- Genome Comparisons betweenJournal of fungi (Basel, Switzerland) · 2024Article
- Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in PathogenicJournal of fungi (Basel, Switzerland) · 2023Article
- Epistatic Relationship betweenJournal of fungi (Basel, Switzerland) · 2023Article
- CRISPR-Cas9 Gene Editing and Secondary Metabolite Screening ConfirmJournal of fungi (Basel, Switzerland) · 2023Article
- Genome and Transcriptome Analysis ofMicrobiology spectrum · 2023Article
- CusProSe: a customizable protein annotation software with an application to the prediction of fungal secondary metabolism genes.Scientific reports · 2023Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fungal secondary metabolite biosynthesis genes are of major interest due to the pharmacological properties of their products (like mycotoxins and antibiotics). The genome of the plant pathogenic fungus Fusarium graminearum codes for a large number of candidate enzymes involved in secondary metabolite biosynthesis. However, the chemical nature of most enzymatic products of proteins encoded by putative secondary metabolism biosynthetic genes is largely unknown. Based on our analysis we present 67 gene clusters with significant enrichment of predicted secondary metabolism related enzymatic functions. 20 gene clusters with unknown metabolites exhibit strong gene expression correlation in planta and presumably play a role in virulence. Furthermore, the identification of conserved and over-represented putative transcription factor binding sites serves as additional evidence for cluster co-regulation. Orthologous cluster search provided insight into the evolution of secondary metabolism clusters. Some clusters are characteristic for the Fusarium phylum while others show evidence of horizontal gene transfer as orthologs can be found in representatives of the Botrytis or Cochliobolus lineage. The presented candidate clusters provide valuable targets for experimental examination.
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