ArticlePloS one2014
Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02619123 (Tailored Screening for Breast Cancer in Premenopausal Women. A Translational, Randomized Population-based Trial), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tailored Screening for Breast Cancer in Premenopausal Women. A Translational, Randomized Population-based Trial
Who cites it
14 citing papers in PubMed.
- A comparison of tumour characteristics of screen-detected and interval cancers and their relationship with breast density and AJCC prognostic stage in a UK screening cohort.European radiology · 2026Article
- Severity and risk factors of interval breast cancer in Queensland, Australia: a population-based study.Breast cancer (Tokyo, Japan) · 2023Article
- Breast Cancer Mode of Detection in a Population-Based Cohort.Mayo Clinic proceedings · 2023Article
- Personalized Screening for Breast Cancer: Rationale, Present Practices, and Future Directions.Annals of surgical oncology · 2021Review
- Breast cancer risk factors by mode of detection among screened women in the Cancer Prevention Study-II.Breast cancer research and treatment · 2021Article
- Interval breast cancer is associated with other types of tumors.Nature communications · 2019Article
- Five-Year Overall Survival of Interval Breast Cancers is Better than Non- Interval Cancers from Korean Breast Cancer Registry.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Differences between screen-detected and interval breast cancers among BRCA mutation carriers.Breast cancer research and treatment · 2019Article
- Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study.Breast cancer research : BCR · 2019Article
- PAM50 and Risk of Recurrence Scores for Interval Breast Cancers.Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Breast cancer risk is increased in the years following false-positive breast cancer screening.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Article
- The epidemiology, radiology and biological characteristics of interval breast cancers in population mammography screening.NPJ breast cancer · 2017Article
- Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha.Oncotarget · 2016Article
- "Screening isn't Your Ticket to Vacation": In-depth Interviews With Women in the United States Who Experienced an Interval Breast Cancer.Cancer control : journal of the Moffitt Cancer CenterArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInterval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes and to compare the risk factors identified with those associated with incident screen-detected cancers.
methodsWe analyzed data from 645,764 women participating in the Spanish breast cancer screening program from 2000-2006 and followed-up until 2009. A total of 5,309 screen-detected and 1,653 interval cancers were diagnosed. Among the latter, 1,012 could be classified on the basis of findings in screening and diagnostic mammograms, consisting of 489 true interval cancers (48.2%), 235 false-negatives (23.2%), 172 minimal-signs (17.2%) and 114 occult tumors (11.3%). Information on the screening protocol and women's characteristics were obtained from the screening program registry. Cause-specific Cox regression models were used to estimate the hazard ratios (HR) of risks factors for interval cancer and incident screen-detected cancer. A multinomial regression model, using screen-detected tumors as a reference group, was used to assess the effect of breast density and other factors on the occurrence of interval cancer subtypes.
resultsA previous false-positive was the main risk factor for interval cancer (HR = 2.71, 95%CI: 2.28-3.23); this risk was higher for false-negatives (HR = 8.79, 95%CI: 6.24-12.40) than for true interval cancer (HR = 2.26, 95%CI: 1.59-3.21). A family history of breast cancer was associated with true intervals (HR = 2.11, 95%CI: 1.60-2.78), previous benign biopsy with a false-negatives (HR = 1.83, 95%CI: 1.23-2.71). High breast density was mainly associated with occult tumors (RRR = 4.92, 95%CI: 2.58-9.38), followed by true intervals (RRR = 1.67, 95%CI: 1.18-2.36) and false-negatives (RRR = 1.58, 95%CI: 1.00-2.49).
conclusionThe role of women's characteristics differs among interval cancer subtypes. This information could be useful to improve effectiveness of breast cancer screening programmes and to better classify subgroups of women with different risks of developing cancer.
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