ArticlePloS one2014
Directional influence between the human amygdala and orbitofrontal cortex at the time of decision-making.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- A Neurocomputational Model of Observation-Based Decision Making with a Focus on Trust.Brain sciences · 2026Article
- Neural Dynamics of Visual Stream Interactions During Memory-Guided Actions Investigated by Intracranial EEG.Neuroscience bulletin · 2025Article
- Computational modeling of attractor-based neural processes involved in the preparation of voluntary actions.Cognitive neurodynamics · 2024Article
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Immediate neural impact and incomplete compensation after semantic hub disconnection.Nature communications · 2023Article
- Mapping effective connectivity of human amygdala subdivisions with intracranial stimulation.Nature communications · 2022Article
- Integrated Amygdala, Orbitofrontal and Hippocampal Contributions to Reward and Loss Coding Revealed with Human Intracranial EEG.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.Frontiers in behavioral neuroscience · 2020Article
- Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids.Frontiers in physiology · 2019Article
- Local Activity and Causal Connectivity in Children with Benign Epilepsy with Centrotemporal Spikes.PloS one · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
There is a growing consensus that the brain makes simple choices, such as choosing between an apple and an orange, by assigning value to the options under consideration, and comparing those values to make a choice. There is also a consensus that value signals computed in orbitofrontal cortex (OFC) and amygdala play a critical role in the choice process. However, the nature of the flow of information between OFC and amygdala at the time of decision is still unknown. In order to study this question, simultaneous local field potentials were recorded from OFC and amygdala in human patients while they performed a simple food choice task. Although the interaction of these circuits has been studied in animals, this study examines the effective connectivity directly in the human brain on a moment-by-moment basis. A spectral conditional Granger causality analysis was performed in order to test if the modulation of activity goes mainly from OFC-to-amygdala, from amygdala-to-OFC, or if it is bi-directional. Influence from amygdala-to-OFC was dominant prior to the revealed choice, with a small but significant OFC influence on the amygdala earlier in the trial. Alpha oscillation amplitudes analyzed with the Hilbert-Huang transform revealed differences in choice valence coincident with temporally specific amygdala influence on the OFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.