ArticlePloS one2014
A combination of Schwann-cell grafts and aerobic exercise enhances sciatic nerve regeneration.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Peripheral nerve repair: innovations and future directions.Journal of translational medicine · 2026Review
- Evaluation of Dexamethasone and Swimming Exercise as Complementary Interventions in a Rat Sciatic Nerve Injury Model.Antioxidants (Basel, Switzerland) · 2025Article
- Combination of Treadmill Training and Inosine Enhance Nerve Regeneration and Functional Recovery After Mice Sciatic Nerve Transection.Journal of neuroscience research · 2025Article
- How Do Peripheral Neurons and Glial Cells Participate in Pain Alleviation by Physical Activity?Cells · 2025Review
- Negative neuromuscular and functional repercussion of forced swimming after axonotmesis.Journal of exercise rehabilitation · 2022Article
- The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal Nerves.Journal of bone metabolism · 2021Article
- Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair.Bioactive materials · 2021Article
- Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction.Aging and disease · 2021Review
- Comparison of morphological and functional outcomes of mouse sciatic nerve repair with three biodegradable polymer conduits containing poly(lactic acid).Neural regeneration research · 2018Article
- Administration of Oxygen Ultra-Fine Bubbles Improves Nerve Dysfunction in a Rat Sciatic Nerve Crush Injury Model.International journal of molecular sciences · 2018Article
- NeurotropinInternational journal of molecular sciences · 2018Article
- A magnetically responsive nanocomposite scaffold combined with Schwann cells promotes sciatic nerve regeneration upon exposure to magnetic field.International journal of nanomedicine · 2017Article
- Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors.Current neuropharmacology · 2017Review
- Promoting peripheral myelin repair.Experimental neurology · 2016Review
- Exercise dependent increase in axon regeneration into peripheral nerve grafts by propriospinal but not sensory neurons after spinal cord injury is associated with modulation of regeneration-associated genes.Experimental neurology · 2016Article
- Tubular conduits, cell-based therapy and exercise to improve peripheral nerve regeneration.Neural regeneration research · 2015Article
- Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury.BioMed research international · 2015Review
- Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve.Frontiers in cellular neuroscience · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite the regenerative potential of the peripheral nervous system, severe nerve lesions lead to loss of target-organ innervation, making complete functional recovery a challenge. Few studies have given attention to combining different approaches in order to accelerate the regenerative process.
objectiveTest the effectiveness of combining Schwann-cells transplantation into a biodegradable conduit, with treadmill training as a therapeutic strategy to improve the outcome of repair after mouse nerve injury.
methodsSciatic nerve transection was performed in adult C57BL/6 mice; the proximal and distal stumps of the nerve were sutured into the conduit. Four groups were analyzed: acellular grafts (DMEM group), Schwann cell grafts (3×105/2 µL; SC group), treadmill training (TMT group), and treadmill training and Schwann cell grafts (TMT + SC group). Locomotor function was assessed weekly by Sciatic Function Index and Global Mobility Test. Animals were anesthetized after eight weeks and dissected for morphological analysis.
resultsCombined therapies improved nerve regeneration, and increased the number of myelinated fibers and myelin area compared to the DMEM group. Motor recovery was accelerated in the TMT + SC group, which showed significantly better values in sciatic function index and in global mobility test than in the other groups. The TMT + SC group showed increased levels of trophic-factor expression compared to DMEM, contributing to the better functional outcome observed in the former group. The number of neurons in L4 segments was significantly higher in the SC and TMT + SC groups when compared to DMEM group. Counts of dorsal root ganglion sensory neurons revealed that TMT group had a significant increased number of neurons compared to DMEM group, while the SC and TMT + SC groups had a slight but not significant increase in the total number of motor neurons.
conclusionThese data provide evidence that this combination of therapeutic strategies can significantly improve functional and morphological recovery after sciatic injury.
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