ArticlePloS one2014
Rampant nuclear insertion of mtDNA across diverse lineages within Orthoptera (Insecta).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
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- Insights into Nuclear Mitochondrial Sequence Distribution in the Pig Genome Based on the Latest Reference Assembly.Animals : an open access journal from MDPI · 2026Article
- DNA barcode reference library of bush-crickets (Orthoptera, Tettigoniidae) from the Iberian Peninsula.Scientific reports · 2025Article
- A Genome-Wide Analysis of Nuclear Mitochondrial DNA Sequences (NUMTs) in Chrysomelidae Species (Coleoptera).Insects · 2025Article
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- Interrogating 1000 insect genomes for NUMTs: A risk assessment for estimates of species richness.PloS one · 2023Article
- Phylogeny and Integrative Taxonomy of the GeneraInsects · 2022Article
- Genome and cuticular hydrocarbon-based species delimitation shed light on potential drivers of speciation in a Neotropical ant species complex.Ecology and evolution · 2022Article
- Species Diversity and Phylogenetic Relationships of Olive Lace Bugs (Hemiptera: Tingidae) Found in South Africa.Insects · 2021Article
- Profile hidden Markov model sequence analysis can help remove putative pseudogenes from DNA barcoding and metabarcoding datasets.BMC bioinformatics · 2021Article
- Ventral dermatitis in rowi (International journal for parasitology. Parasites and wildlife · 2020Article
- Identification of Mitochondrial DNA (NUMTs) in the Nuclear Genome ofInternational journal of molecular sciences · 2020Article
- Comparative Analysis of Genomic Repeat Content in Gomphocerine Grasshoppers Reveals Expansion of Satellite DNA and Helitrons in Species with Unusually Large Genomes.Genome biology and evolution · 2020Article
- Novel Mitochondrial DNA Lineage Found amongInsects · 2020Article
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- Population genetic structure and intraspecific genetic distance ofEcology and evolution · 2019Article
- Prospects and challenges of implementing DNA metabarcoding for high-throughput insect surveillance.GigaScience · 2019Review
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Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear mitochondrial pseudogenes (numts) are non-functional fragments of mtDNA inserted into the nuclear genome. Numts are prevalent across eukaryotes and a positive correlation is known to exist between the number of numts and the genome size. Most numt surveys have relied on model organisms with fully sequenced nuclear genomes, but such analyses have limited utilities for making a generalization about the patterns of numt accumulation for any given clade. Among insects, the order Orthoptera is known to have the largest nuclear genome and it is also reported to include several species with a large number of numts. In this study, we use Orthoptera as a case study to document the diversity and abundance of numts by generating numts of three mitochondrial loci across 28 orthopteran families, representing the phylogenetic diversity of the order. We discover that numts are rampant in all lineages, but there is no discernable and consistent pattern of numt accumulation among different lineages. Likewise, we do not find any evidence that a certain mitochondrial gene is more prone to nuclear insertion than others. We also find that numt insertion must have occurred continuously and frequently throughout the diversification of Orthoptera. Although most numts are the result of recent nuclear insertion, we find evidence of very ancient numt insertion shared by highly divergent families dating back to the Jurassic period. Finally, we discuss several factors contributing to the extreme prevalence of numts in Orthoptera and highlight the importance of exploring the utility of numts in evolutionary studies.
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