ArticlePloS one2014
Large outbreak caused by methicillin resistant Staphylococcus pseudintermedius ST71 in a Finnish Veterinary Teaching Hospital--from outbreak control to outbreak prevention.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 71 citations in OpenAlex.
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- Antimicrobial Resistance Characterization of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Randomized, Blinded, Controlled Clinical Trial of Polylactide-Collagen Scaffold in Treatment of Shoulder Osteochondritis Dissecans in Dogs.Veterinary and comparative orthopaedics and traumatology : V.C.O.T · 2024Article
- Genomic Analyses of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- PRO: Environmental microbiological surveillance does support infection control in veterinary hospitals.JAC-antimicrobial resistance · 2024Article
- Effects ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Risk Factors, Genetic Diversity, and Antimicrobial Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Human Colonization and Infection byMicroorganisms · 2023Review
- Resistome-based surveillance identifies ESKAPE pathogens as the predominant gram-negative organisms circulating in veterinary hospitals.Frontiers in microbiology · 2023Article
- Patterns of antimicrobial, multidrug and methicillin resistance among Staphylococcus spp. isolated from canine specimens submitted to a diagnostic laboratory in Tennessee, USA: a descriptive study.BMC veterinary research · 2022Article
- Isolation and Identification ofVeterinary sciences · 2022Article
- The morbidity and the spectrum of applied drugs in shelter cats in the Czech Republic.Frontiers in veterinary science · 2022Article
- Occurrence and characterization of methicillin-resistant Staphylococcus spp. in diseased dogs in Brazil.PloS one · 2022Article
- Prevalence and Patterns of Antimicrobial Resistance amongVeterinary sciences · 2021Article
- Hand Hygiene Evaluation Using Two Different Evaluation Tools and Hand Contamination of Veterinary Healthcare Workers in a Swiss Companion Animal Clinic.Veterinary sciences · 2021Article
- Hand hygiene compliance in companion animal clinics and practices in Switzerland: An observational study.The Veterinary record · 2021Observational
- Transmission Chains of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae at the Companion Animal Veterinary Clinic-Household Interface.Antibiotics (Basel, Switzerland) · 2021Article
- Higher Prevalence of Extended-Spectrum Cephalosporin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of this study was to describe a nosocomial outbreak caused by methicillin resistant Staphylococcus pseudintermedius (MRSP) ST71 SCCmec II-III in dogs and cats at the Veterinary Teaching Hospital of the University of Helsinki in November 2010 - January 2012, and to determine the risk factors for acquiring MRSP. In addition, measures to control the outbreak and current policy for MRSP prevention are presented.
methodsData of patients were collected from the hospital patient record software. MRSP surveillance data were acquired from the laboratory information system. Risk factors for MRSP acquisition were analyzed from 55 cases and 213 controls using multivariable logistic regression in a case-control study design. Forty-seven MRSP isolates were analyzed by pulsed field gel electrophoresis and three were further analyzed with multi-locus sequence and SCCmec typing.
resultsSixty-three MRSP cases were identified, including 27 infections. MRSPs from the cases shared a specific multi-drug resistant antibiogram and PFGE-pattern indicated clonal spread. Four risk factors were identified; skin lesion (OR = 6.2; CI95% 2.3-17.0, P = 0.0003), antimicrobial treatment (OR = 3.8, CI95% 1.0-13.9, P = 0.0442), cumulative number of days in the intensive care unit (OR = 1.3, CI95% 1.1-1.6, P = 0.0007) or in the surgery ward (OR = 1.1, CI95% 1.0-1.3, P = 0.0401). Tracing and screening of contact patients, enhanced hand hygiene, cohorting and barrier nursing, as well as cleaning and disinfection were used to control the outbreak. To avoid future outbreaks and spread of MRSP a search-and-isolate policy was implemented. Currently nearly all new MRSP findings are detected in screening targeted to risk patients on admission.
conclusionMultidrug resistant MRSP is capable of causing a large outbreak difficult to control. Skin lesions, antimicrobial treatment and prolonged hospital stay increase the probability of acquiring MRSP. Rigorous control measures were needed to control the outbreak. We recommend the implementation of a search-and-isolate policy to reduce the burden of MRSP.
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