ArticlePloS one2014
Theobromine inhibits uric acid crystallization. A potential application in the treatment of uric acid nephrolithiasis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Comparison of Two Dietary Supplements for Treatment of Uric Acid Renal Lithiasis: Citrate vs. Citrate + Theobromine.Nutrients · 2020Trial
- Optimal artificial urine formulations forFrontiers in urology · 2026Article
- Article
- 7-Methylxanthine Inhibits the Formation of Monosodium Urate Crystals by Increasing Its Solubility.Biomolecules · 2023Article
- Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2023Article
- Efficacy of Theobromine and Its Metabolites in Reducing the Risk of Uric Acid Lithiasis.International journal of molecular sciences · 2023Article
- Investigations on melamine-based uric acid kidney stone formation and its prevention by inhibitors.Urolithiasis · 2023Article
- The power of desktop scanning electron microscopy with elemental analysis for analyzing urinary stones.Urolithiasis · 2023Article
- Review
- Differential identification of urine crystals with morphologic characteristics and solubility test.Journal of clinical laboratory analysis · 2022Review
- Effect of theobromine on dissolution of uric acid kidney stones.World journal of urology · 2022Article
- Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.Accounts of chemical research · 2022Article
- New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds.Frontiers in pharmacology · 2022Review
- The Inverted U-Shaped Association of Caffeine Intake with Serum Uric Acid in U.S. Adults.The journal of nutrition, health & aging · 2022Article
- Multishell Au@Ag@SiOMikrochimica acta · 2020Article
- Determination of the structural, electronic, optoelectronic and thermodynamic properties of the methylxanthine molecules theophylline and theobromine.Optical and quantum electronics · 2020Article
- Effect of Consumption of Cocoa-Derived Products on Uric Acid Crystallization in Urine of Healthy Volunteers.Nutrients · 2018Article
- Article
- Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks.Molecules (Basel, Switzerland) · 2016Review
- Assessment of Urinary Inhibitor or Promoter Activity in Uric Acid Nephrolithiasis.The Journal of urology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the capacity of methylxanthines (caffeine, theophylline, theobromine and paraxanthine) to inhibit uric acid crystallization, and to evaluate their potential application in the treatment of uric acid nephrolithiasis. MATERIALS AND
methodsThe ability of methylxathines to inhibit uric acid nucleation was assayed turbidimetrically. Crystal morphology and its modification due to the effect of theobromine were evaluated by scanning electron microscopy (SEM). The ability of theobromine to inhibit uric acid crystal growth on calculi fragments resulting from extracorporeal shock wave lithotripsy (ESWL) was evaluated using a flow system.
resultsThe turbidimetric assay showed that among the studied methylxanthines, theobromine could markedly inhibit uric acid nucleation. SEM images showed that the presence of theobromine resulted in thinner uric acid crystals. Furthermore, in a flow system theobromine blocked the regrowth of post-ESWL uric acid calculi fragments.
conclusionsTheobromine, a natural dimethylxanthine present in high amounts in cocoa, acts as an inhibitor of nucleation and crystal growth of uric acid. Therefore, theobromine may be clinically useful in the treatment of uric acid nephrolithiasis.
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