Evidence map›Paper›PMID 25333398›Full record

GuidelinePancreas2014

American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines.

Darwin L Conwell, Linda S Lee, Dhiraj Yadav, Daniel S Longnecker, Frank H Miller, Koenraad J Mortele, Michael J Levy, Richard Kwon, John G Lieb, Tyler Stevens and 6 more

2 registry-linked trialsAbstract readConsensus StatementPractice Guideline
In one paragraph

Guideline in Pancreas, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 177 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04760847 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Intermittent Fasting as a Primary Means for Improving Quality of Life for Acute and Chronic Pancreatitis

TypeinterventionalSponsorH. Lee Moffitt Cancer Center and Research InstituteRan2026 to 2026Enrolled64ConditionsPancreatitis, Pancreatitis, Acute, Pancreatitis, Chronic, Pancreas DiseaseArmsIntermittent Fasting, No intermittent fasting
NCT07697352 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Randomised, Double-Blind, Non-Inferiority Trial Comparing Microbial and Porcine Pancreatic Enzyme Replacement Therapy in Chronic Pancreatitis

TypeinterventionalSponsorAsian Institute of Gastroenterology, IndiaRan2026 to 2027Enrolled134ConditionsPancreatitis, Chronic, Exocrine Pancreatic Insufficiency (EPI)ArmsDietary Supplement: Pancreatic enzyme preparation from microbial source that contains amylase (6650 DU), lipase (13000 FIP), and protease (7120 HUT, 15 SAPU, 3000 PC)., Standard of care porcine pancreatic enzyme preparation: amylase (8000 U), lipase (25000 U), and protease (1000 U)
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Prevalence of primary painless chronic pancreatitis: A systematic review and meta-analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Pooled it
  4. Biomarkers of Chronic Pancreatitis: A systematic literature review.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Pooled it
  5. Microbiome changes associated with acute and chronic pancreatitis: A systematic review.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021
    Pooled it
  6. Guideline
  7. Pooled it
  8. Pooled it
  9. Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
    Guideline
  10. Reduction of inflammation in chronic pancreatitis using a soy bread intervention: A feasibility study.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020
    Trial
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Idiopathic chronic pancreatitis: clinical highlights.Therapeutic advances in gastroenterology · 2026
    Review
  20. Article

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Darwin L ConwellFrom the *Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH; †Division of Gastroenterology, Hepatology, and Endoscopy, Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA; ‡Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA; §Department of Pathology, The Geisel School of Medicine at Dartmouth, Hanover, NH; ║Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL; ¶Department of Radiology, Beth Israel Deaconness Hospital, Harvard Medical School, Boston, MA; #Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN; **Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI; ††Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA; ‡‡Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH; §§Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, University of Florida, Gainesville, FL; ║║Department of Gastroenterology, University of Chicago, Chicago, IL; and ¶¶Division of Gastroenterology, Department of Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA.
Linda S Lee
Dhiraj Yadav
Daniel S Longnecker
Frank H Miller
Koenraad J Mortele
Michael J Levy
Richard Kwon
John G Lieb
Tyler Stevens
Phillip P Toskes
Timothy B Gardner
Andres Gelrud
Bechien U Wu
Christopher E Forsmark
Santhi S Vege

Funding

Pancreatic Fluid Proteomics in Alcohol Induced Chronic PancreatitisR21DK081703 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI CONWELL, DARWIN LEWIS · 2010 to 2011
$483k
NIDDK NIH HHS R21 DK081703
6 · The paper itself

Abstract

The diagnosis of chronic pancreatitis remains challenging in early stages of the disease. This report defines the diagnostic criteria useful in the assessment of patients with suspected and established chronic pancreatitis. All current diagnostic procedures are reviewed, and evidence-based statements are provided about their utility and limitations. Diagnostic criteria for chronic pancreatitis are classified as definitive, probable, or insufficient evidence. A diagnostic (STEP-wise; survey, tomography, endoscopy, and pancreas function testing) algorithm is proposed that proceeds from a noninvasive to a more invasive approach. This algorithm maximizes specificity (low false-positive rate) in subjects with chronic abdominal pain and equivocal imaging changes. Furthermore, a nomenclature is suggested to further characterize patients with established chronic pancreatitis based on TIGAR-O (toxic, idiopathic, genetic, autoimmune, recurrent, and obstructive) etiology, gland morphology (Cambridge criteria), and physiologic state (exocrine, endocrine function) for uniformity across future multicenter research collaborations. This guideline will serve as a baseline manuscript that will be modified as new evidence becomes available and our knowledge of chronic pancreatitis improves.

Indexed as

CalcinosisCholangiopancreatography, Magnetic ResonanceChymotrypsinDiagnosis, DifferentialDisease ProgressionEndoscopy, Digestive SystemEndosonographyEvidence-Based MedicineFecesHumansIncidencePancreatic ElastasePancreatic Function TestsPancreatic NeoplasmsPancreatitis, AlcoholicPancreatitis, ChronicChymotrypsinPancreatic ElastaseSecretin

Identifiers

PMID25333398
PMCPMC5434978

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.