ReviewAnnals of translational medicine2014
Therapy for metastatic pancreatic neuroendocrine tumors.
Review in Annals of translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Treatment options for PNET liver metastases: a systematic review.World journal of surgical oncology · 2018Pooled it
- Computed tomography features in prediction of histological differentiation of pancreatic neuroendocrine neoplasms - a single-centre retrospective cohort study.Polish journal of radiology · 2024Article
- Current updates and future directions in diagnosis and management of gastroenteropancreatic neuroendocrine neoplasms.World journal of gastrointestinal endoscopy · 2022Review
- Construction and validation of a nomogram for patients with pancreatic neuroendocrine tumors: A population study of 5,927 patients.Frontiers in gastroenterology (Lausanne, Switzerland) · 2022Article
- A real-life treatment cohort of pancreatic neuroendocrine tumors: High-grade increase in metastases confers poor survival.Frontiers in endocrinology · 2022Article
- What Are the Place and Modalities of Surgical Management for Pancreatic Neuroendocrine Neoplasms? A Narrative Review.Cancers · 2021Review
- Evaluation of Pan-SSTRs Targeted Radioligand [ACS medicinal chemistry letters · 2020Article
- The prognostic analysis of different metastatic patterns in pancreatic neuroendocrine tumors patients: A population based analysis.Medicine · 2019Article
- FDA- and EMA-Approved Tyrosine Kinase Inhibitors in AdvancedBiomolecules · 2019Review
- MicroRNA-221 induces autophagy through suppressing HDAC6 expression and promoting apoptosis in pancreatic cancer.Oncology letters · 2018Article
- Selective internal radiation therapy: an effective treatment for hormonal syndromes in pancreatic neuroendocrine tumors.Hepatic oncology · 2018Article
- An isolated metachronous metastasis to the adrenal gland from a pancreatic neuroendocrine tumor: A case report.International journal of surgery case reports · 2017Article
- Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological characteristics and long-term outcomes.Frontiers of medicine · 2016Article
- Health-related quality of life in patients with neuroendocrine tumors: an investigation of treatment type, disease status, and symptom burden.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.BMJ case reports · 2016Article
- Article
- Altered Plasticity of Glycogen Phosphorylase in Forebrain Gliosomes Obtained from Insulinoma Patients.Journal of molecular neuroscience : MN · 2015Article
- Percutaneous Microwave Ablation of an Insulinoma in a Patient with Refractory Symptomatic Hypoglycemia.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- microRNA-218 suppresses the proliferation, invasion and promotes apoptosis of pancreatic cancer cells by targeting HMGB1.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015Article
- Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9/caspase-3 cleavage and Bax-to-Bcl-2 ratio.Bioscience reports · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatic neuroendocrine tumors (pNETs) are frequently malignant (50-80%, except for insulinoma) and may show an aggressive course with metastases to the liver as well as more distant sites. These heterogeneous neoplasms include functioning tumors, which secrete a variety of peptide hormones, and non-functioning tumors (up to 90% of pNETs), which often show metastases at the time of diagnosis.
methodsA PubMed search was performed for English-language publications from 1995 through December 2012. Reference lists from studies selected were manually searched to identify further relevant reports. Manuscripts comparing different therapeutic options and advances for metastatic pNETs were selected.
resultsThe therapeutic options for metastatic pNETs are expanding and include surgery, which remains the only curative approach, liver-directed therapies, and medical therapy. In selected cases also liver transplantation (OLT) may be considered. The option of OLT for metastatic disease is unique to neuroendocrine tumors. Recently, novel promising targeted therapies have been proposed for progressive well-differentiated pNETs.
conclusionsThe best therapeutic approach for pNETs is still matter of debating. However, since pNETs often show a more indolent behavior compared to other malignancies, the preservation of the quality of life of the patient and the personalization of the therapy according to tumor's and patient's features are mandatory.
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