ArticleAnnals of translational medicine2013
Placebo-driven clinical trials of yeast-derived β-(1-3) glucan in children with chronic respiratory problems.
Article in Annals of translational medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of yeast β-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis.European journal of nutrition · 2021Pooled it
- Trial
- A randomised trial of pleuran in paediatric acute gastroenteritis.Scientific reports · 2025Trial
- Effect of Immune-Enhancing Enteral Nutrition Enriched with or without Beta-Glucan on Immunomodulation in Critically Ill Patients.Nutrients · 2016Trial
- Trained Immunity: An Overview and the Impact on COVID-19.Frontiers in immunology · 2022Review
- Beta-(1,3/1,6)-D-glucan fromFrontiers in pediatrics · 2022Article
- Enhancement of β-Glucan Biological Activity Using a Modified Acid-Base Extraction Method fromMolecules (Basel, Switzerland) · 2021Article
- β-1,3/1,6-Glucans and Immunity: State of the Art and Future Directions.Molecular nutrition & food research · 2021Review
- Plant-Derived Nutraceuticals and Immune System Modulation: An Evidence-Based Overview.Vaccines · 2020Review
- Concentration of NK cells after β-glucan and vitamin D supplementation in patients with diabetic retinopathy.Folia microbiologica · 2020Article
- Glucan and Mannan-Two Peas in a Pod.International journal of molecular sciences · 2019Review
- β-glucans and cholesterol (Review).International journal of molecular medicine · 2018Review
- Ingestion of Exopolymers fromEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles.Frontiers in immunology · 2018Review
- Clinical and Physiological Perspectives of β-Glucans: The Past, Present, and Future.International journal of molecular sciences · 2017Review
- Respiratory Tract Infections and the Role of Biologically Active Polysaccharides in Their Management and Prevention.Nutrients · 2017Review
- β-glucan affects mucosal immunity in children with chronic respiratory problems under physical stress: clinical trials.Annals of translational medicine · 2015Article
- Glucan supplementation enhances the immune response against an influenza challenge in mice.Annals of translational medicine · 2015Article
- Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity.Annals of translational medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of glucan in stimulation of immune reactions has been studied for several decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. MATERIALS AND
methodsWe measured the levels of albumin, lysozyme and CRP in saliva of 40 children aged 8-12 years and evaluate the effects of 100 mg/d oral dose of glucan.
resultsWe found a significant increase in production of changes in production of lysozyme and CRP in glucan-treated children. In addition, a strong improvement in general conditions was found.
conclusionsShort-term oral application of natural immunomodulator β-glucan stimulated mucosal immunity of children with chronic respiratory problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.