Evidence map›Paper›PMID 25332768›Full record

ReviewMicrobiome2014

Development of the preterm infant gut microbiome: a research priority.

Maureen W Groer, Angel A Luciano, Larry J Dishaw, Terri L Ashmeade, Elizabeth Miller, Jack A Gilbert

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microbiome, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03235635 (Metagenome Analysis of Intestinal Microbiome in Mortality and Morbidity of Preterm Infants), which is not on this map. Cited by 165 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 5 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03235635 unknown statusnot on this mapstarted 2017, after this paper: background citation

Metagenome Analysis of Intestinal Microbiome in Mortality and Morbidity of Preterm Infants

TypeobservationalSponsorWonju Severance Christian HospitalRan2017 to 2019Enrolled120ConditionsMicrobial Colonization, Microbial Superinvasion, Microbial Substitution, Newborn Morbidity
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 5 syntheses or guidelines pooled it, 275 citations in OpenAlex.

  1. Pooled it
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  4. Systematic Review of the Effect of Enteral Feeding on Gut Microbiota in Preterm Infants.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2018
    Pooled it
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Maureen W GroerUniversity of South Florida College of Nursing, 12910 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
Angel A LucianoDepartment of Pediatrics, Division of Neonatology, Morsani College of Medicine, University of South Florida, Tampa General Cir, Tampa, FL 33606, USA.
Larry J DishawDepartment of Pediatrics, Morsani College of Medicine, ACH Children's Research Institute, USF, 140 7th Avenue South, St. Petersburg, FL 33701, USA.
Terri L AshmeadeDepartment of Pediatrics, Division of Neonatology, Morsani College of Medicine, University of South Florida, Tampa General Cir, Tampa, FL 33606, USA.
Elizabeth MillerDepartment of Anthropology, University of South Florida, 4202 East Fowler Ave., Tampa, FL 33620, USA.
Jack A GilbertInstitute for Genomics and Systems Biology, Argonne National Laboratory, Lemont, IL 60439, USA ; Department of Ecology and Evolution, University of Chicago, 5640 South Ellis Avenue, Chicago, IL 60637, USA ; College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China.
University of South Florida · USArgonne National Laboratory · USUniversity of South Florida St. Petersburg · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. The paper concludes with speculation about how the VLBW infants' gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.

Indexed as

Gut microbiotaHealthPreterm infantsVLBW

Identifiers

PMID25332768
PMCPMC4203464
OpenAlexW2104169043

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.