ArticleJournal of biomedical research2014
Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia.
Article in Journal of biomedical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery.International journal of molecular sciences · 2025Review
- Microwave assisted solvothermal green synthesis of FeScientific reports · 2025Article
- Computational Approaches: A New Frontier in Cancer Research.Combinatorial chemistry & high throughput screening · 2024Review
- Larvicidal and histopathological efficacy of cinnamic acid analogues: a novel strategy to reduce the dengue vector competence.RSC advances · 2022Article
- Hippophae rhamnoides L. leaf and twig extracts as rich sources of nutrients and bioactive compounds with antioxidant activity.Scientific reports · 2022Article
- In-silico analysis of the inhibition of the SARS-CoV-2 main protease by some active compounds from selected African plants.Journal of Taibah University Medical Sciences · 2021Article
- Article
- Reversal Effect of Oxypeucedanin on P-glycoprotein-mediated Drug Transport.Molecules (Basel, Switzerland) · 2018Article
- Novel series of 1,2,4-trioxane derivatives as antimalarial agents.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- Molecular Simulation-based Combinatorial Modeling and Antioxidant Activities of Zingiberaceae Family Rhizomes.Pharmacognosy magazine · 2017Article
- Article
- Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport.Molecules (Basel, Switzerland) · 2016Article
- Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model.Molecules (Basel, Switzerland) · 2016Article
- Sea buckthorn bud extract displays activity against cell-cultured Influenza virus.Journal of preventive medicine and hygiene · 2015Article
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Authors and funding
9 authors.
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Abstract
Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors. H-Ras p21, a member of the Ras-GTPase family, is a promising target to treat various kinds of cancers. An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2. Docking studies revealed that four compounds, isorhamnetin-7-rhamnoside, quercetin-3-glucoside-7-rhamnoside (present in H. rhamnoides), zeaxanthin, and translutein (present in H. salicifolia) significantly bind with binding energies -17.1534, -14.7936, -10.2105 and -17.2217 Kcal/mol, respectively, even though they slightly deviate from Lipinski's rule. Absorption, distribution, metabolism, excretion and toxicity (ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic. Amongst them, isorhamntein-7-rhamnoside showed hepatotoxicity. Hence, these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers.
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