ArticleMutation research2014
Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the Breast Cancer Health Disparities Study.
Article in Mutation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Effect of aspirin use on survival benefits of breast cancer patients: A meta-analysis.Medicine · 2021Pooled it
- Association between oxidative balance score and sarcopenia in older adults.Scientific reports · 2024Article
- Oxidative balance score and dietary phytochemical index can reduce the risk of colorectal cancer in Iranian population.BMC gastroenterology · 2023Article
- Dietary Antioxidant Capacity Indices are Negatively Correlated to LDL-Oxidation in Adults.International journal of clinical practice · 2023Article
- Pre-diagnostic DNA methylation patterns differ according to mammographic breast density amongst women who subsequently develop breast cancer: a case-only study in the EPIC-Florence cohort.Breast cancer research and treatment · 2021Article
- Oxidative balance score and risk of osteoporosis among postmenopausal Iranian women.Archives of osteoporosis · 2021Article
- High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- An atlas of health inequalities and health disparities research: "How is this all getting done in silos, and why?"Social science & medicine (1982) · 2020Article
- The Anti-Proliferative and Anti-Invasive Effect of Leaf Extracts of Blueberry Plants Treated with Methyl Jasmonate on Human Gastric Cancer In Vitro Is Related to Their Antioxidant Properties.Antioxidants (Basel, Switzerland) · 2020Article
- Association between interleukin-10 genetic polymorphisms and risk of primary open angle glaucoma in a Chinese Han population: a case-control study.International journal of ophthalmology · 2019Article
- Beyond Conventional Medicine - a Look at Blueberry, a Cancer-Fighting Superfruit.Pathology oncology research : POR · 2018Review
- Association between Dietary Inflammatory Index (DII) and Risk of Breast Cancer: a Case-Control StudyAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis.Current medical science · 2018Article
- Healthy lifestyle impact on breast cancer-specific and all-cause mortality.Breast cancer research and treatment · 2018Article
- Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation.Journal of translational medicine · 2016Article
- Energy homeostasis genes and survival after breast cancer diagnosis: the Breast Cancer Health Disparities Study.Cancer causes & control : CCC · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
Tumor necrosis factor-α (TNF) and toll-like receptors (TLR) are important mediators of inflammation. We examined 10 of these genes with respect to breast cancer risk and mortality in a genetically admixed population of Hispanic/Native American (NA) (2111 cases, 2597 controls) and non-Hispanic white (NHW) (1481 cases, 1585 controls) women. Additionally, we explored if diet and lifestyle factors modified associations with these genes. Overall, these genes (collectively) were associated with breast cancer risk among women with >70% NA ancestry (P(ARTP) = 0.0008), with TLR1 rs7696175 being the primary risk contributor (OR 1.77, 95% CI 1.25, 2.51). Overall, TLR1 rs7696175 (HR 1.40, 95% CI 1.03, 1.91; P(adj) = 0.032), TLR4 rs5030728 (HR 1.96, 95% CI 1.30, 2.95; P(adj) = 0.014), and TNFRSF1A rs4149578 (HR 2.71, 95% CI 1.28, 5.76; P(adj) = 0.029) were associated with increased breast cancer mortality. We observed several statistically significant interactions after adjustment for multiple comparisons, including interactions between our dietary oxidative balance score and CD40LG and TNFSF1A; between cigarette smoking and TLR1, TLR4, and TNF; between body mass index (BMI) among pre-menopausal women and TRAF2; and between regular use of aspirin/non-steroidal anti-inflammatory drugs and TLR3 and TRA2. In conclusion, our findings support a contributing role of certain TNF-α and TLR genes in both breast cancer risk and survival, particularly among women with higher NA ancestry. Diet and lifestyle factors appear to be important mediators of the breast cancer risk associated with these genes.
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