ArticleNucleic acids research2015
Updates in Rhea--a manually curated resource of biochemical reactions.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
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- Catalysing (organo-)catalysis: Trends in the application of machine learning to enantioselective organocatalysis.Beilstein journal of organic chemistry · 2024Review
- EnzymeMap: curation, validation and data-driven prediction of enzymatic reactions.Chemical science · 2023Article
- Glycoinformatics in the Artificial Intelligence Era.Chemical reviews · 2022Review
- Expanding biochemical knowledge and illuminating metabolic dark matter with ATLASx.Nature communications · 2022Article
- EHreact: Extended Hasse Diagrams for the Extraction and Scoring of Enzymatic Reaction Templates.Journal of chemical information and modeling · 2021Article
- Ten simple rules for creating reusable pathway models for computational analysis and visualization.PLoS computational biology · 2021Article
- A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives.Nature communications · 2021Article
- DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems.BMC systems biology · 2018Article
- Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.Frontiers in pharmacology · 2018Review
- Genome-Wide Prediction of Metabolic Enzymes, Pathways, and Gene Clusters in Plants.Plant physiology · 2017Article
- An update on the Enzyme Portal: an integrative approach for exploring enzyme knowledge.Protein engineering, design & selection : PEDS · 2017Article
- Updates in Rhea - an expert curated resource of biochemical reactions.Nucleic acids research · 2017Article
- MicroScope in 2017: an expanding and evolving integrated resource for community expertise of microbial genomes.Nucleic acids research · 2017Article
- Article
- A stable genetic polymorphism underpinning microbial syntrophy.The ISME journal · 2016Article
- MRE: a web tool to suggest foreign enzymes for the biosynthesis pathway design with competing endogenous reactions in mind.Nucleic acids research · 2016Article
- SensiPath: computer-aided design of sensing-enabling metabolic pathways.Nucleic acids research · 2016Article
- MBROLE 2.0-functional enrichment of chemical compounds.Nucleic acids research · 2016Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive and non-redundant resource of expert-curated biochemical reactions described using species from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Rhea has been designed for the functional annotation of enzymes and the description of genome-scale metabolic networks, providing stoichiometrically balanced enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list and additional reactions), transport reactions and spontaneously occurring reactions. Rhea reactions are extensively curated with links to source literature and are mapped to other publicly available enzyme and pathway databases such as Reactome, BioCyc, KEGG and UniPathway, through manual curation and computational methods. Here we describe developments in Rhea since our last report in the 2012 database issue of Nucleic Acids Research. These include significant growth in the number of Rhea reactions and the inclusion of reactions involving complex macromolecules such as proteins, nucleic acids and other polymers that lie outside the scope of ChEBI. Together these developments will significantly increase the utility of Rhea as a tool for the description, analysis and reconciliation of genome-scale metabolic models.
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