ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2014
Tunable dynamics of microtubule-based active isotropic gels.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 102 citations in OpenAlex.
- Gene-driven self-morphing microtubule-based active matter.Nature materials · 2026Article
- A mechanical ratchet drives unilateral cytokinesis.Nature · 2026Article
- BARCODE: high throughput screening and analysis of soft active materials.Nature communications · 2025Article
- Active membrane deformations of a minimal synthetic cell.Nature physics · 2025Article
- Heterogeneous distribution of kinesin-streptavidin complexes revealed by mass photometry.Soft matter · 2024Article
- Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Self-organization of mortal filaments and its role in bacterial division ring formation.Nature physics · 2024Article
- Dissipation and energy propagation across scales in an active cytoskeletal material.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distribution of activity.Nature communications · 2022Article
- Competing instabilities reveal how to rationally design and control active crosslinked gels.Nature communications · 2022Article
- Cross-linker design determines microtubule network organization by opposing motors.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Extensile to contractile transition in active microtubule-actin composites generates layered asters with programmable lifetimes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Behavior of chiral active nematics confined to nanoscopic circular region.The European physical journal. E, Soft matter · 2021Article
- Active liquid crystals powered by force-sensing DNA-motor clusters.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Flow coupling between active and passive fluids across water-oil interfaces.Scientific reports · 2021Article
- Filamentous active matter: Band formation, bending, buckling, and defects.Science advances · 2020Article
- Tunable corrugated patterns in an active nematic sheet.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- From isolated structures to continuous networks: A categorization of cytoskeleton-based motile engineered biological microstructures.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization.Physical biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigate the dynamics of an active gel of bundled microtubules (MTs) that is driven by clusters of kinesin molecular motors. Upon the addition of ATP, the coordinated action of thousands of molecular motors drives the gel to a highly dynamical turbulent-like state that persists for hours and is only limited by the stability of constituent proteins and the availability of the chemical fuel. We characterize how enhanced transport and emergent macroscopic flows of active gels depend on relevant molecular parameters, including ATP, kinesin motor and depletant concentrations, MT volume fraction, as well as the stoichiometry of the constituent motor clusters. Our results show that the dynamical and structural properties of MT-based active gels are highly tunable. They also indicate existence of an optimal concentration of molecular motors that maximize far-from-equilibrium activity of active isotropic MT gels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.