Evidence map›Paper›PMID 25332329›Full record

Trial reportThe American journal of clinical nutrition2014

High protein intake from meat as complementary food increases growth but not adiposity in breastfed infants: a randomized trial.

Minghua Tang, Nancy F Krebs

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Minghua TangFrom the Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Nancy F KrebsFrom the Section of Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.

Funding

FOSTERING PATIENT ORIENTED RESEARCH IN PEDIATRIC NUTRITIONK24DK083772 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KREBS, NANCY F · 2009 to 2013
$753k
NIDDK NIH HHS K24 DK083772
6 · The paper itself

Abstract

backgroundHigh intake of cow-milk protein in formula-fed infants is associated with higher weight gain and increased adiposity, which have led to recommendations to limit protein intake in later infancy. The impact of protein from meats for breastfed infants during complementary feeding may be different.

objectiveWe examined the effect of protein from meat as complementary foods on growth and metabolic profiles of breastfed infants.

designThis was a secondary analysis from a trial in which exclusively breastfed infants (5-6 mo old from the Denver, CO, metro area) were randomly assigned to receive commercially available pureed meats (Meat group; n = 14) or infant cereal (Cereal group; n = 28) as their primary complementary feedings for ∼ 5 mo. Anthropometric measures and diet records were collected monthly from 5 to 9 mo of age; intakes from complementary feeding and breast milk were assessed at 9 mo of age.

resultsThe Meat group had significantly higher protein intake, whereas energy, carbohydrate, and fat intakes from complementary feeding did not differ by group over time. At 9 mo of age, mean (± SEM) intakes of total (complementary feeding plus breast milk) protein were 2.9 ± 0.6 and 1.4 ± 0.4 g · kg(-1) · d(-1), ∼ 17% and ∼ 9% of daily energy intake, for Meat and Cereal groups, respectively (P < 0.001). From 5 to 9 mo of age, the weight-for-age z score (WAZ) and length-for-age z score (LAZ) increased in the Meat group (ΔWAZ: 0.24 ± 0.19; ΔLAZ: 0.14 ± 0.12) and decreased in the Cereal group (ΔWAZ: -0.07 ± 0.17; ΔLAZ: -0.27 ± 0.24) (P-group by time < 0.05). The change in weight-for-length z score did not differ between groups. Total protein intake at 9 mo of age and baseline WAZ were important predictors of changes in the WAZ (R(2) = 0.23, P = 0.01).

conclusionIn breastfed infants, higher protein intake from meats was associated with greater linear growth and weight gain but without excessive gain in adiposity, suggesting that potential risks of high protein intake may differ between breastfed and formula-fed infants and by the source of protein.

Indexed as

Breast FeedingInfant Nutritional Physiological PhenomenaMeatAdiposityBiomarkersBlood GlucoseBody WeightChild DevelopmentCholesterol, HDLDietary ProteinsDiet RecordsEnergy IntakeFemaleHumansInfantInfant FormulaBiomarkersBlood GlucoseCholesterol, HDLDietary ProteinsInsulinInsulin-Like Growth Factor IInterleukin-6LeptinTriglyceridesTumor Necrosis Factor-alpha

Identifiers

PMID25332329
PMCPMC4196483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.