Evidence map›Paper›PMID 25332317›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2014

Effects of intensive low-salt diet education on albuminuria among nondiabetic patients with hypertension treated with olmesartan: a single-blinded randomized, controlled trial.

Jin Ho Hwang, Ho Jun Chin, Sejoong Kim, Dong Ki Kim, Suhnggwon Kim, Jung Hwan Park, Sung Joon Shin, Sang Ho Lee, Bum Soon Choi, Chun Soo Lim

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 7 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 7 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  3. Altered dietary salt intake for people with chronic kidney disease.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Jin Ho HwangDepartment of Internal Medicine, Chung-Ang University Hospital, Seoul, South Korea;
Ho Jun ChinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seong-Nam, South Korea;
Sejoong KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seong-Nam, South Korea;
Dong Ki KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea;
Suhnggwon KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea;
Jung Hwan ParkDepartment of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea;
Sung Joon ShinDepartment of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea;
Sang Ho LeeDepartment of Internal Medicine, Kyung Hee University Medical Center, Seoul, South Korea;
Bum Soon ChoiDepartment of Internal Medicine, Seoul St. Mary's Hospital, Seoul, South Korea; and.
Chun Soo LimDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea cslimjy@snu.ac.kr.
Seoul National University Bundang Hospital · KRSeoul National University Hospital · KRChung-Ang University Hospital · KRDongguk University · KRKonkuk University · KRKyung Hee University Medical Center · KRSeoul National University · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe antiproteinuric effect of a renin-angiotensin-aldosterone system blockade can be magnified by dietary salt restriction. This study sought to determine the effect of intensive low-salt diet education on BP and urine albumin excretion in nondiabetic patients with hypertension and albuminuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study was conducted between March of 2012 and March of 2013 as an open-label, randomized, controlled trial. After a run-in period of 8 weeks, all patients received the angiotensin II receptor blocker olmesartan (40 mg daily). Patients were then divided into two groups. One group was treated for another 8 weeks with angiotensin II receptor blocker plus conventional low-salt diet education, and the other group was treated for 8 weeks with angiotensin II receptor blocker plus intensive low-salt diet education. The final analyses was performed with 245 completed patients.

resultsThe amount of daily albuminuria was significantly decreased from 0 (566.0 [25.0-5398.6] mg/d) to 8 weeks (282.5 [16.1-4898.5] mg/d; P<0.001). From 8 to 16 weeks, the 24-hour urinary sodium excretion was decreased by 36.0±5.9 mmol/d in the intensive education group and 8.8±4.9 mmol/d in the conventional education group (interaction P<0.001). Patients who completed intensive low-salt diet education exhibited greater decreases in urinary albumin excretion than the control group (change in albuminuria from 8 to 16 weeks, -154.0 versus 0.4 mg/d; P=0.01). Urinary albumin excretion tended to decrease as the 24-hour urinary sodium excretion amount decreased (R=0.32; 95% confidence interval, 0.20 to 0.43; P<0.001).

conclusionsThe 24-hour urinary albumin excretion was decreased more in patients in the intensive low-salt diet education group than patients in the conventional education group. Weekly intensive education on a low-salt diet would be a suitable method for clinical practice.

Indexed as

Diet, Sodium-RestrictedAdultAgedAlbuminuriaAngiotensin II Type 1 Receptor BlockersBlood PressureFemaleFoodHumansHypertensionImidazolesMaleMedication AdherenceMiddle AgedPatient Education as TopicRenal Insufficiency, ChronicAngiotensin II Type 1 Receptor BlockersImidazolesolmesartanSodiumSodium, DietaryTetrazolesalbuminuriaangiotensin systemCKDhypertensionnutritionrennin

Identifiers

PMID25332317
PMCPMC4255393
OpenAlexW2142432209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.