ArticleThe Journal of cell biology2014
Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Autophagy · 2021Guideline
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy · 2016Guideline
- Article
- Association between the AKT1 single nucleotide polymorphism (rs2498786, rs2494752 and rs5811155) and microscopic polyangiitis risk in a Chinese population.Molecular genetics and genomics : MGG · 2023Article
- A phosphoswitch at acinus-serineeLife · 2022Article
- Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.Developmental cell · 2020Article
- Dronc-independent basal executioner caspase activity sustainsProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.Autophagy · 2019Article
- Control of basal autophagy rate by vacuolar peduncle.PloS one · 2019Article
- Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.The Journal of biological chemistry · 2017Article
- Article
- Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth inGenetics · 2017Article
- A quantized mechanism for activation of pannexin channels.Nature communications · 2017Article
- ARC Syndrome-Linked Vps33B Protein Is Required for Inflammatory Endosomal Maturation and Signal Termination.Immunity · 2016Article
- Activated Acinus boosts basal autophagy.Molecular & cellular oncologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
How cellular stresses up-regulate autophagy is not fully understood. One potential regulator is the Drosophila melanogaster protein Acinus (Acn), which is necessary for autophagy induction and triggers excess autophagy when overexpressed. We show that cell type-specific regulation of Acn depends on proteolysis by the caspase Dcp-1. Basal Dcp-1 activity in developing photoreceptors is sufficient for this cleavage without a need for apoptosis to elevate caspase activity. On the other hand, Acn was stabilized by loss of Dcp-1 function or by the presence of a mutation in Acn that eliminates its conserved caspase cleavage site. Acn stability also was regulated by AKT1-mediated phosphorylation. Flies that expressed stabilized forms of Acn, either the phosphomimetic Acn(S641,731D) or the caspase-resistant Acn(D527A), exhibited enhanced basal autophagy. Physiologically, these flies showed improvements in processes known to be autophagy dependent, including increased starvation resistance, reduced Huntingtin-induced neurodegeneration, and prolonged life span. These data indicate that AKT1 and caspase-dependent regulation of Acn stability adjusts basal autophagy levels.
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