Trial reportProceedings of the National Academy of Sciences of the United States of America2014
Disruption of multisystem responses to stress in type 2 diabetes: investigating the dynamics of allostatic load.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of trials of social network interventions in type 2 diabetes.BMJ open · 2017Pooled it
- Effect of 1% HInternational dental journal · 2024Trial
- Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.European journal of endocrinology · 2022Trial
- Cumulative trauma exposure and cardiac autonomic stress reactivity in healthy adults.European journal of psychotraumatology · 2026Article
- Understanding the Relationship Between Weight Discrimination and Cardiometabolic Risk Factors in Diabetes: Findings from the English Longitudinal Study of Ageing (ELSA).International journal of behavioral medicine · 2026Article
- Tailoring interventions to close gaps in diabetes mellitus care.Nature reviews. Endocrinology · 2026Review
- Association between allostatic load and risk of breast carcinoma in situ in the UK biobank.Cancer causes & control : CCC · 2026Article
- Article
- Dysglycemia-Based Chronic Disease and Lifestyle Medicine: Mechanistic Interpretation Using the Allostatic Load Model.American journal of lifestyle medicine · 2026Review
- Stress-related multisystem dysregulation during adolescence predicts mental health symptoms in young adulthood.Psychological medicine · 2025Article
- Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice.Comprehensive Physiology · 2025Article
- Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025Review
- Resilience phenotypes derived from an active inference account of allostasis.Frontiers in behavioral neuroscience · 2025Article
- The Influence of Racial Discrimination as a Chronic Stressor on Type 2 Diabetes Risk and Self-Management Behaviors among Black Adults: A Scoping Review.Current diabetes reports · 2024Article
- Association between child marriage and high blood glucose level in women: A birth cohort analysis.Public health in practice (Oxford, England) · 2024Article
- Association of allostatic load with functional disability in the China Health and Retirement Longitudinal Study.The journal of nutrition, health & aging · 2024Article
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- Association of allostatic load with overall survival in epithelial ovarian cancer.Gynecologic oncology · 2024Observational
- The gender and age perspectives of allostatic load.Frontiers in medicine · 2024Review
- Health-Related Social Control and Perceived Stress Among High-Risk Latina Mothers with Type 2 Diabetes and Their At-Risk Adult Daughters.International journal of behavioral medicine · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Psychological stress-related processes are thought to contribute to the development and progression of type 2 diabetes, but the biological mechanisms involved are poorly understood. Here, we tested the notion that people with type 2 diabetes experience chronic allostatic load, manifest as dynamic disturbances in reactivity to and recovery from stress across multiple (cardiovascular, neuroendocrine, inflammatory, metabolic) biological systems, coupled with heightened experience of chronic life stress. We carried out an experimental comparison of 140 men and women aged 50-75 y with type 2 diabetes and 280 nondiabetic individuals matched on age, sex, and income. We monitored blood pressure (BP) and heart rate, salivary cortisol, plasma interleukin (IL)-6, and total cholesterol in response to standardized mental stress, and assessed salivary cortisol over the day. People with type 2 diabetes showed impaired poststress recovery in systolic and diastolic BP, heart rate and cholesterol, and blunted stress reactivity in systolic BP, cortisol, cholesterol, and IL-6. Cortisol and IL-6 concentrations were elevated, and cortisol measured over the day was higher in the type 2 diabetes group. Diabetic persons reported greater depressive and hostile symptoms and greater stress experience than did healthy controls. Type 2 diabetes is characterized by disruption of stress-related processes across multiple biological systems and increased exposure to life stress. Chronic allostatic load provides a unifying perspective with implications for etiology and patient management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.