ArticleProceedings of the National Academy of Sciences of the United States of America2014
Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein tau.The FEBS journal · 2026Article
- PJA2 Suppresses Colorectal Cancer Progression by Controlling HDAC2 Degradation and Stability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer.Communications biology · 2024Article
- Functional Divergence and Origin of the Vertebrate Praja Family.Journal of molecular evolution · 2024Article
- Ubiquitylation of BBSome is required for ciliary assembly and signaling.EMBO reports · 2023Article
- Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth.Communications biology · 2022Article
- The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.The EMBO journal · 2021Article
- The Ubiquitinated Axon: Local Control of Axon Development and Function by Ubiquitin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains.PloS one · 2021Article
- Implication of Endoplasmic Reticulum Stress in Autism Spectrum Disorder.Neurochemical research · 2018Review
- U24 from Roseolovirus interacts strongly with Nedd4 WW Domains.Scientific reports · 2017Article
- praja2 regulates KSR1 stability and mitogenic signaling.Cell death & disease · 2016Article
- Nogo-A Neutralization Improves Graft Function in a Rat Model of Parkinson's Disease.Frontiers in cellular neuroscience · 2016Article
- Spatiotemporal expression of Nogo-66 receptor after focal cerebral ischemia.Neural regeneration research · 2016Article
- A dynamic interface between ubiquitylation and cAMP signaling.Frontiers in pharmacology · 2015Review
- Extrinsic and intrinsic regulation of axon regeneration at a crossroads.Frontiers in molecular neuroscience · 2015Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein kinase A (PKA) controls major aspects of neurite outgrowth and morphogenesis and plays an essential role in synaptic plasticity and memory. However, the molecular mechanism(s) of PKA action on neurite sprouting and activity are still unknown. Here, we report that in response to neurotrophin or cAMP stimulation the RING ligase praja2 ubiquitinates and degrades NOGO-A, a major inhibitor of neurite outgrowth in mammalian brain. Genetic silencing of praja2 severely inhibited neurite extension of differentiating neuroblastoma cells and mesencephalic neurons and axon outgrowth and sprouting of striatal terminals in developing rat brain. This phenotype was rescued when both praja2 and NOGO-A were depleted, suggesting that NOGO-A is, indeed, a biologically relevant target of praja2 in neuronal cells. Our findings unveil a novel mechanism that functionally couples cAMP signaling with the proteolytic turnover of NOGO-A, positively impacting on neurite outgrowth in mammalian brain.
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