ArticleProceedings of the National Academy of Sciences of the United States of America2014
Baculovirus resistance in codling moth is virus isolate-dependent and the consequence of a mutation in viral gene pe38.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 64 citations in OpenAlex.
- Emergence of new resistances toFrontiers in physiology · 2026Article
- Ecological safety of insecticide based on entomopathogenic virus DsCPV-1 for nontarget invertebrates.Scientific reports · 2024Article
- Transcriptome analysis of CpGV in midguts of type II resistant codling moth larvae and identification of contaminant infections by SNP mapping of RNA-Seq data.Journal of virology · 2024Article
- Assembly and Genome Annotation of Different Strains of Apple Fruit Moth Virus (International journal of molecular sciences · 2024Article
- Increased environmental microbial diversity reduces the disease risk of a mosquitocidal pathogen.mBio · 2024Article
- Cancer immunogenic cell death via pyroptosis with CXCR4-targeted nanotoxins in hepatocellular carcinoma.Frontiers in bioengineering and biotechnology · 2024Article
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- Organic Control Strategies for Use in IPM of Invertebrate Pests in Apple and Pear Orchards.Insects · 2021Review
- Viruses of the Fall ArmywormViruses · 2021Review
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- Generation of Variability inViruses · 2021Article
- CpGV-M Replication in Type I Resistant Insects: Helper Virus and Order of Ingestion Are Important.Viruses · 2021Article
- Transcriptome of Cydia pomonella granulovirus in susceptible and type I resistant codling moth larvae.The Journal of general virology · 2021Article
- Population structure of Cydia pomonella granulovirus isolates revealed by quantitative analysis of genetic variation.Virus evolution · 2021Article
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- Controlled beams of shock-frozen, isolated, biological and artificial nanoparticles.Structural dynamics (Melville, N.Y.) · 2020Article
- Novel Diversity and Virulence Patterns Found in New Isolates of Cydia pomonella Granulovirus from China.Applied and environmental microbiology · 2020Article
- Cryptophlebia peltastica Nucleopolyhedrovirus Is Highly Infectious to Codling Moth Larvae and Cells.Applied and environmental microbiology · 2019Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The baculovirus Cydia pomonella granulovirus (CpGV) is widely applied as a biocontrol agent of codling moth. After field resistance of codling moth populations had been observed against the commercially used Mexican (M) isolate of CpGV, infection experiments of larvae of the resistant codling moth strain CpRR1 showed that several other naturally occurring CpGV isolates (I12, S, E2, and I07) from different geographic origins are still infectious to resistant CpRR1. Whole-genome sequencing and phylogenetic analyses of these geographic CpGV variants revealed that their genomes share only a single common difference from that of CpGV-M, which is a mutation coding for a repeat of 24 nucleotides within the gene pe38; this mutation results in an additional repeat of eight amino acids that appears to be inserted to PE38 of CpGV-M only. Deletion of pe38 from CpGV-M totally abolished virus infection in codling moth cells and larvae, demonstrating that it is an essential gene. When the CpGV-M deletion mutant was repaired with pe38 from isolate CpGV-S, which originated from the commercial product Virosoft and is infectious for the resistant codling moth strain CpRR1, the repaired CpGV-M mutant was found to be fully infectious for CpRR1. Repair using pe38 from CpGV-M restored infectivity for the virus in sensitive codling moth strains, but not in CpRR1. Therefore, we conclude that CpGV resistance of codling moth is directed to CpGV-M but not to other virus isolates. The viral gene pe38 is not only essential for the infectivity of CpGV but it is also the key factor in overcoming CpGV resistance in codling moth.
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