ArticleArthritis care & research2015
A population-based study of infection-related hospital mortality in patients with dermatomyositis/polymyositis.
Article in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 72 citations in OpenAlex.
- Association of malnutrition with in-hospital outcomes among patients hospitalized with dermatomyositis or polymyositis.Clinical rheumatology · 2026Article
- Disease activity and immune disbalance are key drivers of infections in patients with idiopathic inflammatory myopathies: results from the MYOTReCSZ cohort.Immunologic research · 2025Article
- Rehospitalization to evaluate outcomes during clinical courses in patients with elderly-onset idiopathic inflammatory myositis: a retrospective single-center study.Clinical rheumatology · 2025Article
- Development and validation of a nomogram for predicting the incidence of infectious events in patients with idiopathic inflammatory myopathies.Frontiers in immunology · 2025Article
- Influenza knowledge and barriers to vaccination in immunosuppressed patients in the pediatric rheumatology clinic.Pediatric rheumatology online journal · 2024Article
- Long Term Outcomes in Idiopathic Inflammatory Myositis: An Observational Epidemiologic Study over 15 Years.Mediterranean journal of rheumatology · 2023Article
- Clinical Characteristics and Associated Factors for Infection and in-Hospital Mortality in Inpatients with Polymyositis/Dermatomyositis in China: A Retrospective Study.Infection and drug resistance · 2023Article
- Isolated Tuberculous Myositis: A Systematic Review and Multicenter Cases.Journal of rheumatic diseases · 2022Article
- Article
- The lungs were on fire: a pilot study ofArthritis research & therapy · 2021Article
- The spectrum of idiopathic inflammatory myopathies in South Africa.Clinical rheumatology · 2021Article
- Community-Acquired Pneumonia and Hospital-Acquired Pneumonia in Adult Patients with Idiopathic Inflammatory Myopathy: Outcome and Antibiotic Therapy.Rheumatology and therapy · 2021Article
- Clinically amyopathic dermatomyositis presenting with isolated facial edema complicated by acute respiratory failure: a case report.BMC musculoskeletal disorders · 2021Article
- Pneumocystis jirovecii Pneumonia and Other Infections in Idiopathic Inflammatory Myositis.Current rheumatology reports · 2020Review
- Acute Exacerbation of Interstitial Lung Disease in Adult Patients With Idiopathic Inflammatory Myopathies: A Retrospective Case-Control Study.Frontiers in medicine · 2020Article
- Invasive mycoses in patients with connective tissue disease from Southern China: clinical features and associated factors.Arthritis research & therapy · 2019Article
- The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease.Arthritis research & therapy · 2018Article
- Article
- Idiopathic inflammatory myopathies: state of the art on clinical practice guidelines [corrected].RMD open · 2018Review
- Epidemiology and management of healthcare-associated bloodstream infections in non-neutropenic immunosuppressed patients: a review of the literature.Therapeutic advances in infectious disease · 2017Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDermatomyositis (DM) and polymyositis (PM) are debilitating inflammatory myopathies associated with significant mortality. We evaluated the relative contribution of infection to hospital mortality in a large population-based study of individuals with PM/DM.
methodsData derive from the 2007 to 2011 Healthcare Cost and Utilization Project National Inpatient Samples and include all hospital discharges that met a validated administrative definition of PM/DM. The primary outcome was hospital mortality. Variables for infections and comorbidities were generated from discharge diagnoses using validated administrative definitions. Logistic regression was used to investigate the relationship between infection and mortality in individuals with PM/DM, adjusting for sociodemographics, utilization variables, and comorbidities. Relative risks (RRs) were calculated to compare the overall prevalence of specific infections and associated mortality in PM/DM hospitalizations with those seen in the general hospitalized population.
resultsA total of 15,407 hospitalizations with PM/DM met inclusion criteria for this study and inpatient mortality was 4.5% (700 deaths). In adjusted logistic regression analyses, infection (odds ratio [OR] 3.4, 95% confidence interval [95% CI] 2.9-4.0) was the strongest predictor of hospital mortality among individuals with PM/DM. Bacterial infection (OR 3.5, 95% CI 3.0-4.1), comprised primarily of pneumonia and bacteremia, and opportunistic fungal infections (OR 2.5, 95% CI 1.5-4.0) were independently associated with hospital mortality. The overall burden of infection in hospitalizations with PM/DM was significantly increased in comparison with the general hospitalized population (RR 1.5, 95% CI 1.4-1.6).
conclusionAmong hospitalized individuals with PM/DM, infection is the leading cause of mortality. Strategies to mitigate infection risk in both the clinic and hospital settings should be evaluated to improve disease outcomes.
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