ArticleAnnals of gastroenterology2014
The hepatoprotective and hypolipidemic effects of Spirulina (
Article in Annals of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Independent and Synergistic Effect of Spirulina Maxima With Exercise on General Fitness, Lipid Profile and Antioxidant Capacity in Overweight and Obese Subjects
Effects of Spirulina Supplementation on Anthropometric Measurements, Lipid Profile, Appetite, Liver Enzymes, Inflammatory and Glycemic Markers on Overweight or Obese Adults
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Meta-Analysis of the Efficacy of Spirulina Intervention in Mitigating the Negative Impact of Heat Stress on Production Physiology and Health Indices of Broilers.Journal of animal physiology and animal nutrition · 2026Pooled it
- Evidence-Based Supplementation Strategies for Wrestlers: A Systematic Review.Current nutrition reports · 2025Pooled it
- Effect ofNutrients · 2021Pooled it
- Postoperative Spirulina Platensis Supplementation Optimizes Body Composition Improvement without Adverse Effects in Women Undergoing Gastric Bypass: a Pilot Study Randomized and Placebo-Controlled.Obesity surgery · 2026Trial
- Impact of a 12-week High-Intensity Interval Training With Spirulina Supplementation on Insulin Resistance-Mediated by Apo-A, -B, and -J in Men With Obesity HIIT With Spirulina on Apolipoproteins.European journal of sport science · 2025Trial
- Effects of Spirulina supplementation in patients with ulcerative colitis: a double-blind, placebo-controlled randomized trial.BMC complementary medicine and therapies · 2024Trial
- Antioxidant Efficacy of aMarine drugs · 2022Trial
- Review
- Safety evaluation of blue galdieria extract as a food additive.EFSA journal. European Food Safety Authority · 2026Article
- Spirulina-fortified salad dressing on body composition and anthropometric indices in hypertensive patients: A tipple-blind randomized placebo-controlled trial.Caspian journal of internal medicine · 2025Article
- Impact ofScientifica · 2025Review
- Natural Products as Hepatoprotective Agents-A Comprehensive Review of Clinical Trials.Plants (Basel, Switzerland) · 2024Review
- Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats.Nutrients · 2024Article
- Spirulina (Nutrients · 2024Article
- Enhancing cardiometabolic health: unveiling the synergistic effects of high-intensity interval training with spirulina supplementation on selected adipokines, insulin resistance, and anthropometric indices in obese males.Nutrition & metabolism · 2024Article
- Beneficial Effects ofNutrients · 2024Review
- Commentary: Effect of high-doseFrontiers in immunology · 2024Article
- Spirulina Supplementation with High-Intensity Interval Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity.Nutrients · 2023Article
- Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials.Metabolites · 2022Article
- Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI.Frontiers in pharmacology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA pilot study was conducted to determine the effects of Spirulina (
methodsFifteen adult Cretan outpatients (13 men), median age 48 (range: 29-62) years, with NAFLD were orally supplemented with 6 g of Spirulina (Greek production) per day for six months. Anthropometric characteristics (height, weight, waist circumference), systolic and diastolic blood pressure, complete blood count, biochemical assessments, homeostasis model assessment of insulin resistance (HOMA-IR) index, health-related quality of life and abdominal sonographic findings were recorded and measured, before and after Spirulina supplementation.
resultsAt the end of the 6-month intervention period, the mean levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, triglycerides, low-density lipoprotein-cholesterol, total cholesterol, and the ratio of total cholesterol to high-density lipoprotein cholesterol were significantly decreased: 38.5%, 37.5%, 26.7%, 24.8%, 9.6%, 9.1%, and 13.5% respectively, whereas the mean levels of high-density lipoprotein-cholesterol and hemoglobin were significantly increased: 4.2% and 4.1% respectively. Spirulina supplementation resulted also in a significant reduction in weight and HOMA-IR index (8.1% and 19.6% respectively) and a significant improvement in health-related quality of life scale. No changes in sonographic findings were observed.
conclusionSpirulina supplementation at a high dosage of 6 g daily in NAFLD patients has strong and multiple beneficial metabolic effects and improves their health-related quality of life.
Indexed as
Identifiers
25331487PMC4188938W2115947907What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.