ArticleJournal of bacteriology2015
Loss of FliL alters Proteus mirabilis surface sensing and temperature-dependent swarming.
Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Flagellar protein FliL: A many-splendored thing.Molecular microbiology · 2024Review
- Unveiling the hidden arsenal: new insights intoFrontiers in cellular and infection microbiology · 2024Review
- Flagellar motor remodeling during swarming requires FliL.Molecular microbiology · 2023Article
- A correlation study between virulence factors and multidrug resistance among clinical isolates of Proteus mirabilis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Flagellar motor remodeling during swarming requires FliL.bioRxiv : the preprint server for biology · 2023Article
- The FilZ Protein Contains a Single PilZ Domain and Facilitates the Swarming Motility ofMicroorganisms · 2023Article
- FliL Functions in Diverse Microbes to Negatively Modulate Motor Output via Its N-Terminal Region.mBio · 2023Article
- Metabolic reconstruction of the near complete microbiome of the model sponge Ianthella basta.Environmental microbiology · 2023Article
- FliL and its paralog MotF have distinct roles in the stator activity of the Sinorhizobium meliloti flagellar motor.Molecular microbiology · 2022Article
- How Can a Histidine Kinase Respond to Mechanical Stress?Frontiers in microbiology · 2021Article
- Transcriptome Analysis of Two Strains of Proteus mirabilis with Swarming Migration Deficiency Isolated from Patients with Urinary Tract Infection.Current microbiology · 2020Article
- Characterization of FliL Proteins in Bradyrhizobium diazoefficiens: Lateral FliL Supports Swimming Motility, and Subpolar FliL Modulates the Lateral Flagellar System.Journal of bacteriology · 2020Article
- Inhibitors of Bacterial Swarming Behavior.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- How bacteria recognise and respond to surface contact.FEMS microbiology reviews · 2020Review
- Functional Regulators of Bacterial Flagella.Annual review of microbiology · 2019Review
- FliL association with flagellar stator in the sodium-driven Vibrio motor characterized by the fluorescent microscopy.Scientific reports · 2018Article
- SwrD (YlzI) Promotes Swarming in Bacillus subtilis by Increasing Power to Flagellar Motors.Journal of bacteriology · 2018Article
- Reassessing the role of the Escherichia coli CpxAR system in sensing surface contact.PloS one · 2018Article
- Torque, but not FliL, regulates mechanosensitive flagellar motor-function.Scientific reports · 2017Article
- Imaging the motility and chemotaxis machineries in Helicobacter pylori by cryo-electron tomography.Journal of bacteriology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteus mirabilis is a dimorphic motile bacterium well known for its flagellum-dependent swarming motility over surfaces. In liquid, P. mirabilis cells are 1.5- to 2.0-μm swimmer cells with 4 to 6 flagella. When P. mirabilis encounters a solid surface, where flagellar rotation is limited, swimmer cells differentiate into elongated (10- to 80-μm), highly flagellated swarmer cells. In order for P. mirabilis to swarm, it first needs to detect a surface. The ubiquitous but functionally enigmatic flagellar basal body protein FliL is involved in P. mirabilis surface sensing. Previous studies have suggested that FliL is essential for swarming through its involvement in viscosity-dependent monitoring of flagellar rotation. In this study, we constructed and characterized ΔfliL mutants of P. mirabilis and Escherichia coli. Unexpectedly and unlike other fliL mutants, both P. mirabilis and E. coli ΔfliL cells swarm (Swr(+)). Further analysis revealed that P. mirabilis ΔfliL cells also exhibit an alteration in their ability to sense a surface: e.g., ΔfliL P. mirabilis cells swarm precociously over surfaces with low viscosity that normally impede wild-type swarming. Precocious swarming is due to an increase in the number of elongated swarmer cells in the population. Loss of fliL also results in an inhibition of swarming at <30°C. E. coli ΔfliL cells also exhibit temperature-sensitive swarming. These results suggest an involvement of FliL in the energetics and function of the flagellar motor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.