ArticleAnnals of biomedical engineering2015
Macrophages modulate engineered human tissues for enhanced vascularization and healing.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 76 citations in OpenAlex.
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- Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges.Life (Basel, Switzerland) · 2026Review
- Reciprocal macrophage-MSC crosstalk drives immunomodulatory and regenerative phenotypes in a mineralized collagen scaffold.bioRxiv : the preprint server for biology · 2026Article
- High mobility group box 1: DAMPening the danger molecule in cardiovascular disease with exercise.Cell stress & chaperones · 2026Review
- Anti-CD31 antibody preconditioning for enhancement of endothelial cell capture and vascularization: a novel strategy for bioengineering lung scaffolds.Journal of biological engineering · 2026Article
- Macrophage Mechano-Responsiveness Within Three-Dimensional Tissue Matrix upon Mechanotherapy-Associated Strains.Tissue engineering. Part A · 2024Article
- Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype.Frontiers in immunology · 2024Article
- Vascularized Tissue Organoids.Bioengineering (Basel, Switzerland) · 2023Review
- The function of immunomodulation and biomaterials for scaffold in the process of bone defect repair: A review.Frontiers in bioengineering and biotechnology · 2023Review
- Methods for vascularization and perfusion of tissue organoids.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Blood Vessel Detection Algorithm for Tissue Engineering and Quantitative Histology.Annals of biomedical engineering · 2022Article
- Bioreactors for Vocal Fold Tissue Engineering.Tissue engineering. Part B, Reviews · 2022Review
- Research Progress on the Immunogenicity and Regeneration of Acellular Adipose Matrix: A Mini Review.Frontiers in bioengineering and biotechnology · 2022Review
- Application of Epigallocatechin-3-gallate (EGCG) Modified 1-Ethyl-3-(3-dimethylaminopropylcarbodiimide hydrochloride/N-hydroxy-succinimide (EDC/NHS) Cross-Linked Collagen Membrane to Promote Macrophage Adhesion.Materials (Basel, Switzerland) · 2021Article
- Article
- Decellularised Human Umbilical Artery as a Vascular Graft Elicits Minimal Pro-Inflammatory Host Response Ex Vivo and In Vivo.International journal of molecular sciences · 2021Article
- Effects of Process Parameters on Structure and Properties of Melt-Blown Poly(Lactic Acid) Nonwovens for Skin Regeneration.Journal of functional biomaterials · 2021Article
- Biomaterial design strategies to address obstacles in craniomaxillofacial bone repair.RSC advances · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Tissue engineering is increasingly based on recapitulating human physiology, through integration of biological principles into engineering designs. In spite of all progress in engineering functional human tissues, we are just beginning to develop effective methods for establishing blood perfusion and controlling the inflammatory factors following implantation into the host. Functional vasculature largely determines tissue survival and function in vivo. The inflammatory response is a major regulator of vascularization and overall functionality of engineered tissues, through the activity of different types of macrophages and the cytokines they secrete. We discuss here the cell-scaffold-bioreactor systems for harnessing the inflammatory response for enhanced tissue vascularization and healing. To this end, inert scaffolds that have been considered for many decades a "gold standard" in regenerative medicine are beginning to be replaced by a new generation of "smart" tissue engineering systems designed to actively mediate tissue survival and function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.